| Content Provider |
World Health Organization (WHO)-Global Index Medicus |
| Author |
Summers, D. M. Johnson, R. J. Hudson, A. J. Collett, D. Murphy, P. Watson, C. J. E. Neuberger, J. M. Bradley, J. A. |
| Description |
Country affiliation: United kingdom Author Affiliation: Summers DM ( Department of Surgery, School of Clinical Medicine, University of Cambridge, Addenbrooke's Hospital, Box 202, Cambridge CB2 0QQ, UK Cambridge National Institute for Health Research Biomedical Research Centre, Cambridge, UK NHS Blood and Transplant, Bristol, UK dms39@cam.ac.uk.); Johnson RJ ( NHS Blood and Transplant, Bristol, UK.); Hudson AJ ( NHS Blood and Transplant, Bristol, UK.); Collett D ( NHS Blood and Transplant, Bristol, UK.); Murphy P ( NHS Blood and Transplant, Bristol, UK.); Watson CJ ( Department of Surgery, School of Clinical Medicine, University of Cambridge, Addenbrooke's Hospital, Box 202, Cambridge CB2 0QQ, UK Cambridge National Institute for Health Research Biomedical Research Centre, Cambridge, UK.); Neuberger JM ( NHS Blood and Transplant, Bristol, UK.); Bradley JA ( Department of Surgery, School of Clinical Medicine, University of Cambridge, Addenbrooke's Hospital, Box 202, Cambridge CB2 0QQ, UK Cambridge National Institute for Health Research Biomedical Research Centre, Cambridge, UK.) |
| Abstract |
BACKGROUND: The UK has implemented a national strategy for organ donation that includes a centrally coordinated network of specialist nurses in organ donation embedded in all intensive care units and a national organ retrieval service for deceased organ donors. We aimed to determine whether despite the national approach to donation there is significant regional variation in deceased donor kidney donation rates. METHODS: The UK prospective audit of deaths in critical care was analysed for a cohort of patients who died in critical care between April 2010 and December 2011. Multivariate logistic regression was used to identify the factors associated with kidney donation. The logistic regression model was then used to produce risk-adjusted funnel plots describing the regional variation in donation rates. RESULTS: Of the 27 482 patients who died in a critical care setting, 1528 (5.5%) became kidney donors. Factors found to influence donation rates significantly were: type of critical care [e.g. neurointensive vs general intensive care: OR 1.53, 95% confidence interval (CI) 1.34-1.75, P<0.0001], patient ethnicity (e.g. 'Asian' vs 'white': OR 0.17, 95% CI 0.11-0.26, P<0.0001), age (e.g. age >69 vs age 18-39 yr: OR 0.2, 0.15-0.25, P<0.0001), and cause of death [e.g. 'other' (excluding 'stroke' and 'trauma') vs 'trauma': OR 0.04, 95% CI 0.03-0.05, P<0.0001]. Despite correction for these variables, kidney donation rates for the 20 UK kidney donor regions showed marked variation. The overall standardized donation rate ranged from 3.2 to 7.5%. Four regions had donation rates of >2 standard deviations (sd) from the mean (two below and two above). Regional variation was most marked for donation after circulatory death (DCD) kidney donors with 9 of the 20 regions demonstrating donation rates of >2 sd from the mean (5 below and 4 above). CONCLUSIONS: The marked regional variation in kidney donation rates observed in this cohort after adjustment for factors strongly associated with donation rates suggests that there is considerable scope for further increasing kidney donation rates in the UK, particularly DCD. |
| File Format |
HTM / HTML |
| ISSN |
00070912 |
| e-ISSN |
14716771 |
| DOI |
10.1093/bja/aet473 |
| Journal |
British Journal of Anaesthesia |
| Issue Number |
1 |
| Volume Number |
113 |
| Language |
English |
| Publisher |
Oxford University Press |
| Publisher Date |
2014-07-01 |
| Publisher Place |
Great Britain (UK) |
| Access Restriction |
Open |
| Subject Keyword |
Discipline Anesthesiology Kidney Transplantation Statistics & Numerical Data Tissue Donors Supply & Distribution Tissue And Organ Procurement Organization & Administration Adolescent Cause Of Death Cohort Studies Critical Care Nursing Ethnic Groups Intensive Care Units Prospective Studies Tissue And Organ Harvesting Epidemiology Research Support, Non-u.s. Gov't |
| Content Type |
Text |
| Resource Type |
Article |
| Subject |
Anesthesiology and Pain Medicine |
