NDLI: Feasibility of measuring memory response to increasing dexmedetomidine sedation in children.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Mason, K. P. Kelhoffer, E. R. Prescilla, R. Mehta, M. Root, J. C. Young, V. J. Robinson, F. Veselis, R. A.
Description	Country affiliation: United States Author Affiliation: Mason KP ( Department of Anesthesia, Harvard Medical School, Boston Children's Hospital, Boston, MA, USA keira.mason@childrens.harvard.edu.); Kelhoffer ER ( Department of Anesthesiology and Critical Care, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.); Prescilla R ( Department of Anesthesiology, Weill Cornell Medical College, New York, NY, USA.); Mehta M ( Department of Anaesthesiology, Perioperative and Pain Medicine, Harvard Medical School, MA, USA.); Root JC ( Department of Anesthesiology and Critical Care, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.); Young VJ ( Department of Anesthesiology, Weill Cornell Medical College, New York, NY, USA.); Robinson F ( Department of Anesthesiology and Critical Care, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.); Veselis RA ( Department of Anesthesiology, Weill Cornell Medical College, New York, NY, USA.)
Abstract	BACKGROUND: The memory effect of dexmedetomidine has not been prospectively evaluated in children. We evaluated the feasibility of measuring memory and sedation responses in children during dexmedetomidine sedation for non-painful radiological imaging studies. Secondarily, we quantified changes in memory in relation to the onset of sedation. METHODS: A 10 min bolus of dexmedetomidine (2 mcg kg ) was given to children as they named simple line drawings every five s. The absence of sedation was identified as any verbal response, regardless of correctness. After recovery, recognition memory was tested with correct Yes/No recognitions (50% novel pictures) and was matched to sedation responses during the bolus period (subsequent memory paradigm). RESULTS: Of 64 accruals, 30 children (mean [SD]6.1 (1.2) yr, eight male) received dexmedetomidine and completed all study tasks. Individual responses were able to be modelled successfully in the 30 children completing all the study tasks, demonstrating feasibility of this approach. Children had 50% probability of verbal response at five min 40 s after infusion start, whereas 50% probability of subsequent recognition memory occurred sooner at four min five s. CONCLUSIONS: Quantifying memory and sedation effects during dexmedetomidine infusion in verbal children was possible and demonstrated that memory function was present until shortly before verbal unresponsiveness occurred. This is the first study to investigate the effect of dexmedetomidine on memory in children. CLINICAL TRIAL REGISTRATION: NCT 02354378.
File Format	HTM / HTML
ISSN	00070912
e-ISSN	14716771
Journal	British Journal of Anaesthesia
Issue Number	2
Volume Number	118
Language	English
Publisher	Oxford University Press
Publisher Date	2017-02-01
Publisher Place	Great Britain (UK)
Access Restriction	Open
Subject Keyword	Anaesthesia
Content Type	Text
Resource Type	Article
Subject	Anesthesiology and Pain Medicine

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