NDLI: Perioperative -receptor blockade in phaeochromocytoma surgery: an observational case series.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Groeben, H. Nottebaum, B. J. Alesina, P. F. Traut, A. Neumann, H. P. Walz, M. K.
Description	Author Affiliation: Groeben H ( Department of Anaesthesiology, Critical Care Medicine and Pain Therapy h.groeben@kliniken-essen-mitte.de.); Nottebaum BJ ( Department of Anaesthesiology, Critical Care Medicine and Pain Therapy.); Alesina PF ( Department of Surgery and Center of Minimal Invasive Surgery.); Traut A ( Department of Gynecology and Gynecologic Oncology, Kliniken Essen-Mitte, Essen, Germany.); Neumann HP ( Department of Nephrology and General Medicine, University Medical Center, Albert-Ludwigs-University, Freiburg, Germany.); Walz MK ( Department of Surgery and Center of Minimal Invasive Surgery.)
Abstract	BACKGROUND: Mortality associated with surgery for phaeochromocytoma has dramatically decreased over the last decades. Many factors contributed to the dramatic decline of the mortality rate, and the influence of an -receptor blockade is unclear and has never been tested in a randomized trial. We evaluated intraoperative haemodynamic conditions and the incidence of complications in patients with and without -receptor blockade undergoing surgery for catecholamine producing tumours. METHODS: Haemodynamic conditions and perioperative complications were assessed in 110 patients with (B) and 166 without (N) -receptor blockade. Data were analysed as a consecutive case series of 303 cases and subsequently via propensity score matching, and presented as mean and confidence interval (CI). RESULTS: No difference in maximal intraoperative systolic arterial pressures (B = 178 mm Hg (CI 169-187) vs N = 185 mm Hg (CI 177-193; P = 0.2542) and hypertensive episodes above 250 mm Hg were found (P = 0.7474) for the closed case series. No major complications occurred. Propensity score matching (75 pairs) revealed a significant difference of 17 mm Hg in maximal intraoperative systolic bp for these selected pairs (P = 0.024). CONCLUSIONS: Only a slight difference in mean maximal systolic arterial pressure was detected between patients with or without an -receptor blockade. There was no difference in the incidence of excessive hypertensive episodes between groups and no major complications occurred. The basis for the general recommendation of perioperative - receptor blockade for phaeochromocytoma surgery demands further study.
File Format	HTM / HTML
ISSN	00070912
e-ISSN	14716771
Journal	British Journal of Anaesthesia
Issue Number	2
Volume Number	118
Language	English
Publisher	Oxford University Press
Publisher Date	2017-02-01
Publisher Place	Great Britain (UK)
Access Restriction	Open
Subject Keyword	Anaesthesia
Content Type	Text
Resource Type	Article
Subject	Anesthesiology and Pain Medicine

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in