NDLI: Endovascular treatment of experimental aneurysms with use of fibroblast transfected with replication-deficient adenovirus containing bone morphogenetic protein-13 gene.

Please wait, while we are loading the content...

Endovascular treatment of experimental aneurysms with use of fibroblast transfected with replication-deficient adenovirus containing bone morphogenetic protein-13 gene.

Diffusion tensor imaging and fiber tractography in Parry-Romberg syndrome.

Substantia nigra MR imaging signal changes and cardiomyopathy following prenatal exposure to cocaine and heroin.

PHACES syndrome: from the brain to the face via the neural crest cells.

Pleomorphic adenoma with extensive ossified and calcified degeneration: unusual CT findings in one case.

Detection of CSF leak in spinal CSF leak syndrome using MR myelography: correlation with radioisotope cisternography.

Vertebroplasty in multiple myeloma: outcomes in a large patient series.

MR imaging-based evidence of vasogenic brain edema in a case of acute acetone intoxication.

Advances in spinal cord MR angiography.

Transluminal angioplasty and stenting for intracranial vertebrobasilar occlusive lesions in acute stroke patients.

Mechanisms of occlusion and recanalization in canine carotid bifurcation aneurysms embolized with platinum coils: an alternative concept.

Quantitative estimation of permeability surface-area product in astroglial brain tumors using perfusion CT and correlation with histopathologic grade.

Experimental study of intracranial hematoma detection with flat panel detector C-arm CT.

PHACES association: a neuroradiologic review of 17 patients.

Monitoring of clopidogrel-related platelet inhibition: correlation of nonresponse with clinical outcome in supra-aortic stenting.

Balancing radiation dose and image quality: clinical applications of neck volume CT.

Increased cochlear fluid-attenuated inversion recovery signal in patients with vestibular schwannoma.

Resolution of existing intimal plaque in a patient with carotidynia.

Neurologic complications of inferior petrosal sinus sampling.

Aberrant midsagittal fiber tracts in patients with hemimegalencephaly.

Diffusion tensor MR imaging in cervical spine trauma.

High-resolution imaging of an ancient Egyptian mummified head: new insights into the mummification process.

Parotid gland oncocytosis: CT findings with histopathologic correlation.

MR spectroscopy of a bright cerebellar lesion in a patient with Langerhans cell histiocytosis.

ATM--OMG!

Intracranial stenting of severe symptomatic intracranial stenosis: results of 100 consecutive patients.

Diffusion tensor MR imaging and fiber tractography: theoretic underpinnings.

Quantitative differentiation between healthy and disordered brain matter in patients with neurofibromatosis type I using diffusion tensor imaging.

Benefits and dangers of university-sponsored open-access systems.

Year: 2008 Volume: 29 Issue: 3

Year: 2008 Volume: 29 Issue: 2

Year: 2008 Volume: 29 Issue: 1

Endovascular treatment of experimental aneurysms with use of fibroblast transfected with replication-deficient adenovirus containing bone morphogenetic protein-13 gene.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Dai, D. Ding, Y. H. Danielson, M. A. Kadirvel, R. Helm, G. A. Lewis, D. A. Cloft, H. J. Kallmes, D. F.
Description	Country affiliation: United States Author Affiliation: Dai D ( Neuroradiology Research Laboratory, Department of Radiology, Mayo Clinic, Rochester, MN 55905, USA.)
Abstract	BACKGROUND AND PURPOSE: Modified coils have failed to improve long-term recanalization of aneurysms. This study examined whether ex vivo transduction of replication-deficient adenovirus containing the bone morphogenetic protein-13 gene (Ad-BMP-13) in fibroblast allografts would improve angiographic results via increased collagen synthesis, compared with fibroblast-coated platinum coils (FBC) and bare platinum coils (PA). MATERIALS AND METHODS: Aneurysms were embolized with Ad-BMP-13-coated coils (n = 20). Rabbits were sacrificed at 14 days and at 1, 3, and 6 months after implantation. Digital subtraction angiography (DSA) evaluated stability after embolization. Histologic specimens were examined with a qualitative grading system. Masson trichrome evaluated collagen deposition. Findings were compared with previously reported controls for PA and FBC in the same model and time points. RESULTS: The grading system showed a greater total score (P = .0002) in Ad-BMP-13 (6.8 +/- 1.6) and FBC (6.3 +/- 2.4) compared with PA (4.7 +/- 2.4). A group main effects test showed that aneurysm neck tissue coverage in Ad-BMP-13 (2.5 +/- 1.1) was higher (P = .0007) than both FBC (1.6 +/- 1.4) and PA (0.9 +/- 1.1). Ad-BMP-13 had more (P < .0001) collagen deposition than the FBC and PA. One- and 3-month Ad-BMP-13 collagen depositions increased (P < .05) over the FBC and PA. Finally, Ad-BMP-13 showed radiographic stability in 15 (75%) cases, coil compaction in 4 (20%) cases, and progressive occlusion in 1 (5%) case. There were no differences in angiographic results (P = .6522). CONCLUSION: The Ad-BMP-13-coated coils can improve neck coverage and dome fibrosis in the rabbit model, even in the absence of observed differences in angiographic outcome.
File Format	HTM / HTML
ISSN	01956108
e-ISSN	1936959X
DOI	10.3174/ajnr.A0892
Journal	American Journal of Neuroradiology
Issue Number	4
Volume Number	29
Language	English
Publisher	American Journal of Neuroradiology
Publisher Date	2008-04-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Neurology Discipline Radiology Adenoviridae Genetics Bone Morphogenetic Proteins Coated Materials, Biocompatible Embolization, Therapeutic Instrumentation Fibroblasts Transplantation Intracranial Aneurysm Therapy Transfection Metabolism Angiography, Digital Subtraction Animals Cerebral Angiography Collagen Biosynthesis Platinum Rabbits Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Radiology, Nuclear Medicine and Imaging Neurology (clinical)

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Endovascular Treatment of Experimental Aneurysms With Use of Fibroblast Transfected With Replication-Deficient Adenovirus Containing

Matrix² coils in embolization of intracranial aneurysms: 1-year outcome and comparison with bare platinum coil group in a single institution.

ENDOVASCULAR TREATMENT OF EXPERIMENTAL ANEURYSMS USING FIBROBLAST TRANSFECTED WITH REPLICATION-DEFICIENT ADENOVIRUS CONTAINING BONE MORPHOGENETIC PROTEIN-13 GENE

MRA versus DSA for follow-up of coiled intracranial aneurysms: a meta-analysis.

HydroSoft coil versus HydroCoil for endovascular aneurysm occlusion study: a single center experience.

Comparison of bioactive coils and bare platinum coils for treatment of intracranial aneurysms: a matched-pair analysis.

Hydrogel-coated coils versus bare platinum coils for the endovascular treatment of intracranial aneurysms (HELPS): a randomised controlled trial.

One-Year Angiographic Follow-Up after WEB-SL Endovascular Treatment of Wide-Neck Bifurcation Intracranial Aneurysms.

Vascular geometry change because of endovascular stent placement for anterior communicating artery aneurysms.

Endovascular treatment of experimental aneurysms with use of fibroblast transfected with replication-deficient adenovirus containing bone morphogenetic protein-13 gene.

Similar Documents

Endovascular Treatment of Experimental Aneurysms With Use of Fibroblast Transfected With Replication-Deficient Adenovirus Containing

Matrix² coils in embolization of intracranial aneurysms: 1-year outcome and comparison with bare platinum coil group in a single institution.

ENDOVASCULAR TREATMENT OF EXPERIMENTAL ANEURYSMS USING FIBROBLAST TRANSFECTED WITH REPLICATION-DEFICIENT ADENOVIRUS CONTAINING BONE MORPHOGENETIC PROTEIN-13 GENE

MRA versus DSA for follow-up of coiled intracranial aneurysms: a meta-analysis.

HydroSoft coil versus HydroCoil for endovascular aneurysm occlusion study: a single center experience.

Comparison of bioactive coils and bare platinum coils for treatment of intracranial aneurysms: a matched-pair analysis.

Hydrogel-coated coils versus bare platinum coils for the endovascular treatment of intracranial aneurysms (HELPS): a randomised controlled trial.

One-Year Angiographic Follow-Up after WEB-SL Endovascular Treatment of Wide-Neck Bifurcation Intracranial Aneurysms.

Vascular geometry change because of endovascular stent placement for anterior communicating artery aneurysms.

Endovascular treatment of experimental aneurysms with use of fibroblast transfected with replication-deficient adenovirus containing bone morphogenetic protein-13 gene.