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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Chen, Xiaojia Lu, Jia Ji, Yuhua Hong, An Xie, Qiuling |
| Description | Author Affiliation: Chen X ( Guangdong Provincial Key Laboratory of Bioengineering Medicine, Guangzhou, 510632, China, tchenxj@jnu.edu.cn.) |
| Abstract | Bone is one of the most common metastatic sites for breast cancer. In this study, we observed a promoting effect of osteoblast-conditioned medium (OCM) on the migration of MCF-7, a noninvasive cell line of breast cancer cells. Cytokine antibody array was used to compare the cytokines of OCM with the conditioned medium of non-differentiated osteoblast cells, which consequently revealed factors related to migration, such as IL8, IL6, CSF2 (G-CSF), CSF3 (GM-CSF), and TNFRSF11B (osteoprotegerin). The expression of genes related to migration was also estimated with a PCR array, which showed that 9 genes were upregulated and 26 genes downregulated. Moreover, activated p38, ERK, and AKT pathways were found in the OCM treatment group. This finding indicated the migration ability of breast cancer cells, which move toward the bone depending on the presence of specific cytokines in its surrounding microenvironment. |
| File Format | HTM / HTML |
| ISSN | 10104283 |
| Issue Number | 1 |
| Volume Number | 35 |
| e-ISSN | 14230380 |
| Journal | Tumor Biology |
| Language | English |
| Publisher | Springer |
| Publisher Date | 2014-01-01 |
| Publisher Place | Netherlands |
| Access Restriction | Subscribed |
| Subject Keyword | Discipline Medicine__semicolon__oncology Breast Neoplasms Metabolism Cell Movement Drug Effects Cytokines Osteoblasts Genetics Pathology Cell Line, Tumor Culture Media, Conditioned Pharmacology Female Humans Mcf-7 Cells Rna, Messenger Signal Transduction Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Cancer Research |
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