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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Pinheiro, Ugo Borges de Carvalho Fraga, Carlos Alberto Mendes, Danilo Cangussu Marques-Silva, Luciano Farias, Lucyana Conceição de Souza, Marcela Gonçalves Soares, Mariana Batista Jones, Kimberly Marie Santos, Sérgio Henrique Souza de Paula, Alfredo Maurício Batista Velásquez-Meléndez, Gustavo Guimarães, André Luiz |
| Description | Country affiliation: Brazil Author Affiliation: Pinheiro UB ( Department of Dentistry, Universidade Estadual de Montes Claros, Hospital Universitário Clemente de Faria, Avenida Cula Mangabeira, 562, Montes Claros, Minas Gerais, 39400-000, Brazil.) |
| Abstract | Head and neck squamous cell carcinoma (HNSCC) is considered a serious public health problem in many countries. Recently, genetic variations have been considered as important factors to cancer susceptibility and prognosis. More specifically, genetic polymorphisms have been associated with the development and prognosis of HNSCC. The purpose of the current study was to investigate an association among p16 (CDKN2A) gene polymorphism at rs11515, age, and HNSCC aggressiveness. PCR-RFLP analysis was used to investigate the p16 (CDKN2A) gene in 96 patients with HNSCC and in 100 individuals without HNSCC. A case group was categorized by age in younger (<60 years) and older (≥ 60 years) patients. Differences between the case and control groups were determined using Fisher and chi-squared tests. Time of survival was calculated from the date of diagnosis to the date of last follow-up visit or to the date of death using the Kaplan-Meier estimator and comparing this to the log-rank test. Statistical significance was set at p<0.05. In the present study, no association was established between HNSCC and rs11515 polymorphism, as indicated in a previous study. We found that HNSCC individuals with large-sized tumors and with metastatic disease presented worse overall survival, consistent with fundamental concepts that establish the effects of tumor size and lymph node metastasis to HNSCC outcomes. This study identified that there is no difference in the distribution of rs11515 between the control and HNSCC groups. In addition, no differences between rs11515 genotypes and clinicopathological parameters were observed. |
| File Format | HTM / HTML |
| ISSN | 10104283 |
| Issue Number | 6 |
| Volume Number | 35 |
| e-ISSN | 14230380 |
| Journal | Tumor Biology |
| Language | English |
| Publisher | Springer |
| Publisher Date | 2014-06-01 |
| Publisher Place | Netherlands |
| Access Restriction | Subscribed |
| Subject Keyword | Discipline Medicine__semicolon__oncology Carcinoma, Squamous Cell Genetics Head And Neck Neoplasms Neoplasm Proteins Polymorphism, Single Nucleotide Adult Aged Mortality Pathology Female Humans Male Middle Aged Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Cancer Research |
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