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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Gu, Xiao-yan Wang, Jun Luo, Yi-zhou Du, Qiang Li, Ruo-ran Shi, Hui Yu, Tian-pei |
| Description | Author Affiliation: Gu XY ( Department of Rehabilitation, The 454th Hospital of Chinese PLA, Nanjing, Jiangsu, 210002, China, guxiaoyan05@126.com.) |
| Abstract | Non-small-cell lung cancer (NSCLC) is one of the most common causes of cancer-related death. Our investigations show that miR-150 is a typical microRNA that is overexpressed in human NSCLC. We characterized the effects of miR-150 overexpression in NSCLC cells and found that down-regulation of miR-150 expression inhibited cell proliferation and induced cell apoptosis in vitro; additionally, up-regulation of miR-150 levels had the opposite effect on tumor growth and progression. Furthermore, we found that the mechanism of the miR-150 effects on NSCLC cells was associated with alterations in the expression of human BRI1-associated receptor kinase 1 (BAK1). miR-150 may function as an oncogene in NSCLC cells by directly targeting BAK1. Thus, these data highlight a novel molecular interaction between miR-150 and BAK1 and provide a novel strategy for NSCLC therapy via the down-regulation of miR-150 expression. |
| File Format | HTM / HTML |
| ISSN | 10104283 |
| Issue Number | 6 |
| Volume Number | 35 |
| e-ISSN | 14230380 |
| Journal | Tumor Biology |
| Language | English |
| Publisher | Springer |
| Publisher Date | 2014-06-01 |
| Publisher Place | Netherlands |
| Access Restriction | Subscribed |
| Subject Keyword | Discipline Medicine__semicolon__oncology Apoptosis Carcinoma, Non-small-cell Lung Pathology Cell Proliferation Lung Neoplasms Micrornas Physiology Bcl-2 Homologous Antagonist-killer Protein Antagonists & Inhibitors Down-regulation Humans Analysis Genetics Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Cancer Research |
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