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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Rad, Seyed Mohammad Ali Hosseini Langroudi, Lida Kouhkan, Fatemeh Yazdani, Laleh Koupaee, Alireza Nouri Asgharpour, Sara Shojaei, Zahra Bamdad, Taravat Arefian, Ehsan |
| Description | Author Affiliation: Rad SM ( Department of Molecular Biology and Genetic Engineering, Stem Cell Technology Research Center, 1997775555, Tehran, Iran, a.hoseini.rad@gmail.com.) |
| Abstract | Gene therapy as a therapeutic approach has been the dream for many scientists around the globe. Many strategies have been proposed and applied for this purpose, yet the void for a functional safe method is still apparent. Since most of the diseases are caused by undesirable upregulation (oncogenes) or downregulation (tumor suppressor genes) of genes, major gene therapy's techniques affect gene expression. Most of the methods are used in post-transcriptional level such as RNA inhibitory (RNAi) and splice-switching oligonucleotides (SSOs). RNAi blocks messenger RNA (mRNA) translation by mRNA degradation or interruption between attachments of mRNA with ribosomes' subunits. However, one of the novel methods is the usage of transcription factor targeted decoys. DNA decoys are the new generation of functional gene downregulatory oligonucleotides which compete with specific binding sites of transcription factors. Considering the exponential growth of this technique in both in vitro and in vivo studies, in this paper, we aim to line out the description, design, and application of decoys in research and therapy. |
| File Format | HTM / HTML |
| ISSN | 10104283 |
| Issue Number | 7 |
| Volume Number | 36 |
| e-ISSN | 14230380 |
| Journal | Tumor Biology |
| Language | English |
| Publisher | Springer |
| Publisher Date | 2015-07-01 |
| Publisher Place | Netherlands |
| Access Restriction | Subscribed |
| Subject Keyword | Discipline Medicine__semicolon__oncology Genetic Therapy Neoplasms Genetics Therapy Transcription Factors Transcription, Genetic Binding Sites Gene Expression Regulation, Neoplastic Humans Nf-kappa B Oligodeoxyribonucleotides Therapeutic Use Rna Interference Rna, Messenger Journal Article Review |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Cancer Research |
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