NDLI: Synergistic effect between celecoxib and luteolin is dependent on estrogen receptor in human breast cancer cells.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Jeon, Ye Won Ahn, Young Ee Chung, Won Sang Choi, Hyun Joo Suh, Young Jin
Description	Author Affiliation: Jeon YW ( Department of Surgery, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, 93 Joongboo-Daero Paldal-gu, Suwon, 442-723, Kyounggi-do, Republic of Korea.)
Abstract	The anti-cancer effects of celecoxib and luteolin are well known. Although our previous study demonstrated that the combination of celecoxib and luteolin synergistically inhibits breast tumor growth compared with each of the treatments alone, we did not uncover the molecular mechanisms of these effects. The aims of our present study were to compare the effects of a celecoxib and luteolin combination treatment in four different human breast cell lines and to determine the mechanisms of action in vitro and in vivo. The synergistic effects of a celecoxib and luteolin combination treatment yielded significantly greater cell growth inhibition in all four breast cancer cell lines compared with the single agents alone. In particular, combined celecoxib and luteolin treatment significantly decreased the growth of MDA-MB-231 cancer cells in vivo compared with either agent alone. The celecoxib and luteolin combination treatment induced synergistic effects via Akt inactivation and extracellular signal-regulated kinase (ERK) signaling inhibition in MCF-7 and MCF7/HER18 cells and via Akt inactivation and ERK signaling activation in MDA-MB-231 and SkBr3 cells. These results demonstrate the synergistic anti-tumor effect of the celecoxib and luteolin combination treatment in different four breast cancer cell lines, thus introducing the possibility of this combination as a new treatment modality.
File Format	HTM / HTML
ISSN	10104283
Issue Number	8
Volume Number	36
e-ISSN	14230380
Journal	Tumor Biology
Language	English
Publisher	Springer
Publisher Date	2015-08-01
Publisher Place	Netherlands
Access Restriction	Subscribed
Subject Keyword	Discipline Medicine__semicolon__oncology Breast Neoplasms Drug Therapy Cell Proliferation Drug Effects Drug Synergism Estrogen Receptor Alpha Biosynthesis Animals Apoptosis Genetics Pathology Celecoxib Female Humans Luteolin Administration & Dosage Map Kinase Signaling System Mcf-7 Cells Mice Proto-oncogene Proteins C-akt Pyrazoles Receptor, Erbb-2 Sulfonamides Xenograft Model Antitumor Assays Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Medicine Cancer Research

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