NDLI: Down-regulation of miR-489 contributes into NSCLC cell invasion through targeting SUZ12.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Xie, Zongtao Cai, Liming Li, Runsheng Zheng, Jinyu Wu, Hongyan Yang, Xiaoqi Li, Hu Wang, Zhiqiang
Description	Country affiliation: China Author Affiliation: Xie Z ( Department of Thoracic and Cardiovascular Surgery, Affiliated Hospital of Jiangnan University, The Forth People's Hospital of Wuxi City, No. 200, Huihe Road, Wuxi, 214062, China.)
Abstract	microRNAs are small, non-coding RNAs that contribute into various biological processes during cancer progression. However, the potential role of miR-489 in the development of Non-Small Cell Lung Cancer (NSCLC) is not demonstrated. In present study, miR-489 was down-regulated both in tumor tissues and cells. Inhibition of miR-489 promoted cells invasion by using an invasion assay. Furthermore, miR-489 could regulate SUZ12 as shown by luciferase reporter and Western blot assays. Aberrant miR-489 expression could regulate the molecular changes (E-cadherin, N-cadherin, and Vimentin) of epithelial mesenchymal transition (EMT). In conclusion, our study revealed that miR-489 may play an essential role in the progression of NSCLC.
File Format	HTM / HTML
ISSN	10104283
Issue Number	8
Volume Number	36
e-ISSN	14230380
Journal	Tumor Biology
Language	English
Publisher	Springer
Publisher Date	2015-08-01
Publisher Place	Netherlands
Access Restriction	Subscribed
Subject Keyword	Discipline Medicine__semicolon__oncology Tumor Markers, Biological Biosynthesis Carcinoma, Non-small-cell Lung Genetics Micrornas Neoplasm Invasiveness Polycomb Repressive Complex 2 Aged Apoptosis Pathology Cell Line, Tumor Cell Proliferation Epithelial-mesenchymal Transition Female Gene Expression Regulation, Neoplastic Humans Male Middle Aged Journal Article
Content Type	Text
Resource Type	Article
Subject	Medicine Cancer Research

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