NDLI: Esculin and its oligomer fractions inhibit adhesion and migration of U87 glioblastoma cells and in vitro angiogenesis.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Mokdad-Bzeouich, Imen Kovacic, Hervé Ghedira, Kamel Chebil, Latifa Ghoul, Mohamed Chekir-Ghedira, Leila Luis, José
Description	Country affiliation: Tunisia Author Affiliation: Mokdad-Bzeouich I ( Laboratoire de biologie cellulaire et moléculaire. Faculté de Médecine dentaire. Université de Monastir, Rue Avicenne, Monastir, 5000, Tunisie.); Kovacic H ( Unité de Substances Naturelles Bioactives et Biotechnologie UR12ES12, Faculté de Pharmacie de Monastir, Université de Monastir, Rue Avicenne, Monastir, 5000, Tunisie.); Ghedira K ( INSERM UMR 911-CRO2, Faculté de Pharmacie, Aix-Marseille Université, Marseille, France.); Chebil L ( Unité de Substances Naturelles Bioactives et Biotechnologie UR12ES12, Faculté de Pharmacie de Monastir, Université de Monastir, Rue Avicenne, Monastir, 5000, Tunisie.); Ghoul M ( Laboratoire d'Ingénierie des Biomolécules, ENSAIA-INPL, Université de Lorraine, Vandoeuvre-lès-Nancy, France.); Chekir-Ghedira L ( Laboratoire d'Ingénierie des Biomolécules, ENSAIA-INPL, Université de Lorraine, Vandoeuvre-lès-Nancy, France.); Luis J ( Laboratoire de biologie cellulaire et moléculaire. Faculté de Médecine dentaire. Université de Monastir, Rue Avicenne, Monastir, 5000, Tunisie. leila.chekir@laposte.net.)
Abstract	Cancer metastasis is the major cause of cancer-related death. Chemoprevention is defined as the use of natural or synthetic substances to prevent cancer formation or cancer progress. In the present study, we investigate the antitumor activity of esculin and its oligomer fractions in U87 glioblastoma cells. We showed that esculin and its oligomers reduced U87 cell growth in a dose dependent manner. They also inhibited cell adhesion to collagen IV and vitronectin by interfering with the function of their respective receptors 2ß1 and vß5 integrins. Furthermore, the tested samples were able to reduce migration of U87 cells towards another extracellular matrix fibronectin. Moreover, esculin and its oligomer fractions inhibited in vitro angiogenesis of endothelial cells (HMEC-1). In summary, our data provide the first evidence that esculin and its oligomer fractions are able to reduce adhesion, migration of glioblastoma cells and in vitro angiogenesis. Esculin and its oligomers may thus exert multi-target functions against cancer cells.
File Format	HTM / HTML
ISSN	10104283
Issue Number	3
Journal	Tumor Biology
Volume Number	37
e-ISSN	14230380
Language	English
Publisher	Springer
Publisher Date	2016-03-01
Publisher Place	Netherlands
Access Restriction	Subscribed
Content Type	Text
Resource Type	Article
Subject	Medicine Cancer Research

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