NDLI: Intramedullary cavity as implantation site for bioartifical pancreas: preliminary in vivo study.

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Results of kidney transplantation from donors after cardiac death.

Predonation quality of life and early postdonation safety of older living renal donors in China.

Risk factors for delayed graft function after hand-assisted laparoscopic donor nephrectomy.

Living donor renal transplantation using grafts with multiple arteries procured by laparoscopic nephrectomy.

Factors associated with changes in coagulation profiles after living donor hepatectomy.

Kidney grafts from HCV-positive donors: advantages and disadvantages.

Vasopressor agents after experimental brain death: effects of dopamine and vasopressin on vitality of the small gut.

Role of vascular endothelial growth factor in protection of intrahepatic cholangiocytes mediated by hypoxic preconditioning after liver transplantation in rats.

Diluted blood reperfusion as a model for transplantation of ischemic rat livers: alanine aminotransferase is a direct indicator of viability.

Clinical analysis of living related renal transplantation with donors older than 50 years in China.

Outcome of the using older donors for kidney transplantation;Gazi University, Ankara experience.

Association between the heme oxygenase-1 promoter polymorphism and renal transplantation outcome in Greece.

Time of occurrence of kidney acute antibody-mediated allograft rejection/acute cellular rejection and cell senescence: implications for function outcome.

Optimized technique in needle biopsy protocol shown to be of greater sensitivity and accuracy compared to wedge biopsy.

Third and fourth kidney transplant: still a reasonable option.

Evaluation of cinacalcet HCl treatment after kidney transplantation.

Correlation between HLA and posttransplantation diabetes mellitus in the Han population in South China.

Effect of apolipoprotein E gene polymorphism on serum lipid level before and after renal transplantation.

Bone disease in renal transplantation and pleotropic effects of vitamin D therapy.

Molecular epidemiology of Epstein-Barr virus in adult kidney transplant recipients.

Influence of long-term dialysis treatment on operative complications after renal transplantation.

Signal transducer and activator of transcription 1 and matrix metalloproteinase 3 genetic expression and clinical significance on urothelial tumors after renal transplantation.

Dermatologic findings in renal transplant recipients: Possible effects of immunosuppression regimen and p53 mutations.

Targeting risk factors for impaired wound healing and wound complications after kidney transplantation.

Sirolimus-induced isometric tubular vacuolization: a new sirolimus histopathologic manifestation.

Gynecologic symptoms and sexual function in female kidney allograft recipients.

Erectile dysfunction in living donor kidney transplant recipients associated with chronic hepatitis B infection.

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Peritransplant monitoring of immune cell function in adult living donor liver transplantation.

Timing of conversion to mammalian target of rapamycin inhibitors is crucial in liver transplant recipients with impaired renal function at transplantation.

Cardiovascular risk factors and immunosuppressive regimen after liver transplantation.

Sirolimus in liver transplant recipients: a large single-center experience.

Effect of right ventricular dysfunction on dynamic preload indices to predict a decrease in cardiac output after inferior vena cava clamping during liver transplantation.

Thromboelastography-guided transfusion decreases intraoperative blood transfusion during orthotopic liver transplantation: randomized clinical trial.

Serum vasopressin concentrations during orthotopic liver transplantation.

Influence of immunosuppressive drugs on the development of CD4(+)CD25(high) Foxp3(+) T cells in liver transplant recipients.

Introduction of mycophenolate mofetil in maintenance liver transplant recipients: what can we expect? Results of a 10-year experience.

The technique and outcomes of branch-patch arterial reconstruction in living donor liver transplantation.

Quality of life and psychologic distress of recipients after adult living-donor liver transplantation (LDLT)-A study from mainland China.

Safety and effectiveness of intensive insulin protocol use in post-operative liver transplant recipients.

Comparison of the molecular adsorbent recirculating system and plasmapheresis for patients with graft dysfunction after liver transplantation.

Outcomes of patients who develop symptomatic Clostridium difficile infection after solid organ transplantation.

Cytomegalovirus infection after liver transplantation incidence, risks, and benefits of prophylaxis.

Graft loss and poor outcomes after living-donor liver transplantation owing to arterioportal shunts caused by liver needle biopsies.

Simultaneous pancreas-kidney transplantation: which organ should be transplanted first?

Outcomes after simultaneous pancreas and kidney transplantation and the discriminative ability of the C-peptide measurement pretransplant among type 1 and type 2 diabetes mellitus.

Cartilage oligomeric matrix protein-angiopoientin-1 enhances angiogenesis of isolated islet and maintains normoglycemia following transplantation.

Suppressor of cytokine signaling 1 inhibits apoptosis of islet grafts through caspase 3 and apoptosis-inducing factor pathways in rats.

Prolongation of islet graft survival using concomitant transplantation of islets and vascular endothelial cells in diabetic rats.

Intramedullary cavity as implantation site for bioartifical pancreas: preliminary in vivo study.

Histologic features of cytomegalovirus enteritis in small bowel allografts.

Acute rejection of small intestine allografts is associated with increased expression of toll-like receptors.

Resting alveolar gas tensions as a mortality prognosticator in chronic heart failure.

Effect of blood product transfusion-induced tolerance on incidence of cardiac allograft rejection.

Sirolimus is associated with impaired hematopoiesis in heart transplant patients? A retrospective analysis.

Atrial flutter after heart transplantation: mechanism and catheter ablation.

Gastroesophageal reflux disease is associated with an increased rate of acute rejection in lung transplant allografts.

Lung transplantation for severe antineutrophilic cytoplasmic antibody-associated vasculitis.

The impact of bone marrow fibrosis on the outcome of hematopoietic stem cell transplantation.

Vascular endothelium changes after conditioning in hematopoietic stem cell transplantation: role of cyclophosphamide and busulfan.

Micafungin does not influence the concentration of tacrolimus in patients after allogeneic hematopoietic stem cell transplantation.

Microdystrophin delivery in dystrophin-deficient (mdx) mice by genetically-corrected syngeneic MSCs transplantation.

The impact of early rehabilitation on the duration of hospitalization in patients after allogeneic hematopoietic stem cell transplantation.

Streptozotocin-induced diabetic rat-derived bone marrow mesenchymal stem cells have impaired abilities in proliferation, paracrine, antiapoptosis, and myogenic differentiation.

Correlation between the immature characteristics of umbilical cord blood-derived mesenchymal stem cells and engraftment of hematopoietic stem cells in NOD/SCID mice.

Mast cell protease 6 is required for allograft tolerance.

Eotaxin/CCL11 levels correlate with myocardial fibrosis and mast cell density in native and transplanted rat hearts.

An experimental approach toward chronic pulmonary allograft rejection: Orthotopic lung versus heterotopic tracheal segment transplantation in rats.

Effect of pyruvate and HEPES on rat lung allograft acidosis and cell death after long-term hypothermic storage.

Combined application of blocking antibodies and MicroRNA interference in inhibiting CD44 expression.

Hepatoprotective effect of an immortal human fetal hepatic cell transplantation on CCL(4)-induced acute liver injury in mice.

Establishment of a porcine model for lobar lung auto-transplantation.

Serial monitoring of B-type natriuretic Peptide in management of heart failure after liver transplantation in a patient with Budd-Chiari syndrome: case report.

Successful treatment of invasive mucormycosis in a liver transplant patient by arm amputation.

Macrophage-dominant sialadenitis in human T-cell leukemia virus type I-associated myelopathy after living-donor liver transplantation.

Combined liver-kidney transplantation complicated by intraoperative discovery of a bronchobiliary fistula.

Acute allograft renal failure with marked hyperuricemia developing during mizoribine administration: a case report with review of the literature.

Post-kidney transplantation lymphocele due to a lymphatic filariasis.

Cost of paid transplantation abroad: possible donor-origin early multiple myeloma in a renal transplant recipient treated using bortezomib.

Successful bone marrow transplantation reveals the lack of endothelial progenitor cells mobilization in a patient with critical limb ischemia: a case report.

RE: Emergency liver transplantation after umbilical hernia repair: A case report.

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Intramedullary cavity as implantation site for bioartifical pancreas: preliminary in vivo study.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Yang, K-C Wu, C-C Kuo, Z-F Yang, C-Y Lin, F-H
Description	Country affiliation: Japan Author Affiliation: Yang KC ( Department of Organ Reconstruction, Institute for Frontier Medical Sciences, Kyoto University, Japan.)
Abstract	BACKGROUND: The intramedullary cavity is a widely distributed well-vascularized microenvironment capable of sustaining grafts, and is a potential site for islet transplantation. The bone marrow offers sufficient space that may also be suitable for bioartificial pancreas (BAP) implantation. OBJECTIVE: To evaluate the feasibility of bone marrow as an implantation site for BAPs. MATERIALS AND METHODS: A calcium phosphate cement chamber satisfies the criteria for immunoisolation. Mouse insulinoma cells were suspended with agarose gel and enclosed in a calcium phosphate cement chamber to create a BAP, which was implanted in the intramuscular space in diabetic swine or the intramedullary cavity in diabetic dogs. Blood glucose and C-peptide concentrations were determined perioperatively. RESULTS: In the swine, the mean ± SD blood glucose concentration decreased from 413 ± 24 mg/dL to 285 ± 47 mg/dL, and was maintained in the range of 285 to 336 mg/dL for 15 days. It increased to 368 to 450 mg/dL after the BAPs were implanted in the intramuscular space. In the dogs, the blood glucose concentration decreased from 422 ± 32 mg/dL to 247 ± 52 mg/dL, and was maintained in the range of 247 to 347 mg/dL after the BAPs were implanted in the intramedullary cavity. The C-peptide concentration increased from 6.1 ± 2.8 pmol/L to 104.7 ± 16.4 pmol/L when the BAPs were implanted in the intramedullary cavity. CONCLUSION: This study indicates superior effectiveness of BAPs implanted in the intramedullary cavity compared with the intramuscular space. This observation may be attributed to the greater oxygen tension in the bone marrow. The BAPs in direct contact with the circulatory system receive sufficient blood flow for function and survival. This preliminary study demonstrates that the intramedullary cavity may be an implantation site for BAP transplantation.
File Format	HTM / HTML
ISSN	00411345
Issue Number	7
Volume Number	42
e-ISSN	18732623
Journal	Transplantation Proceedings
Language	English
Publisher	Elsevier
Publisher Date	2010-09-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Transplantation__semicolon__medicine Bioartificial Organs Utilization Insulinoma Pathology Kidney Medulla Surgery Pancreas Transplantation Methods Animals Blood Glucose Metabolism Bone Cements Bone Marrow Anatomy & Histology C-peptide Blood Dogs Mice Prostheses And Implants Swine Journal Article
Content Type	Text
Resource Type	Article
Subject	Transplantation Surgery

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