NDLI: Timing of conversion to mammalian target of rapamycin inhibitors is crucial in liver transplant recipients with impaired renal function at transplantation.

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Living donor renal transplantation using grafts with multiple arteries procured by laparoscopic nephrectomy.

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Kidney grafts from HCV-positive donors: advantages and disadvantages.

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Clinical analysis of living related renal transplantation with donors older than 50 years in China.

Outcome of the using older donors for kidney transplantation;Gazi University, Ankara experience.

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Gynecologic symptoms and sexual function in female kidney allograft recipients.

Erectile dysfunction in living donor kidney transplant recipients associated with chronic hepatitis B infection.

Does hepatorenal syndrome affect the result of liver transplantation? Clinical observations.

Peritransplant monitoring of immune cell function in adult living donor liver transplantation.

Timing of conversion to mammalian target of rapamycin inhibitors is crucial in liver transplant recipients with impaired renal function at transplantation.

Cardiovascular risk factors and immunosuppressive regimen after liver transplantation.

Sirolimus in liver transplant recipients: a large single-center experience.

Effect of right ventricular dysfunction on dynamic preload indices to predict a decrease in cardiac output after inferior vena cava clamping during liver transplantation.

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Serum vasopressin concentrations during orthotopic liver transplantation.

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Quality of life and psychologic distress of recipients after adult living-donor liver transplantation (LDLT)-A study from mainland China.

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Cytomegalovirus infection after liver transplantation incidence, risks, and benefits of prophylaxis.

Graft loss and poor outcomes after living-donor liver transplantation owing to arterioportal shunts caused by liver needle biopsies.

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Prolongation of islet graft survival using concomitant transplantation of islets and vascular endothelial cells in diabetic rats.

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Effect of pyruvate and HEPES on rat lung allograft acidosis and cell death after long-term hypothermic storage.

Combined application of blocking antibodies and MicroRNA interference in inhibiting CD44 expression.

Hepatoprotective effect of an immortal human fetal hepatic cell transplantation on CCL(4)-induced acute liver injury in mice.

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Successful treatment of invasive mucormycosis in a liver transplant patient by arm amputation.

Macrophage-dominant sialadenitis in human T-cell leukemia virus type I-associated myelopathy after living-donor liver transplantation.

Combined liver-kidney transplantation complicated by intraoperative discovery of a bronchobiliary fistula.

Acute allograft renal failure with marked hyperuricemia developing during mizoribine administration: a case report with review of the literature.

Post-kidney transplantation lymphocele due to a lymphatic filariasis.

Cost of paid transplantation abroad: possible donor-origin early multiple myeloma in a renal transplant recipient treated using bortezomib.

Successful bone marrow transplantation reveals the lack of endothelial progenitor cells mobilization in a patient with critical limb ischemia: a case report.

RE: Emergency liver transplantation after umbilical hernia repair: A case report.

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Timing of conversion to mammalian target of rapamycin inhibitors is crucial in liver transplant recipients with impaired renal function at transplantation.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Schleicher, C. Palmes, D. Utech, M. Bonrath, E. Senninger, N. Schmidt, H. Wolters, H.
Description	Country affiliation: Germany Author Affiliation: Schleicher C ( Department of General and Visceral Surgery, University of Muenster, Germany. christina.schleicher@ukmuenster.de)
Abstract	BACKGROUND: Renal dysfunction, primarily related to long-term use of calcineurin inhibitor-based immunosuppression, is the most common complication after liver transplantation. OBJECTIVE: To evaluate whether liver transplant recipients with impaired kidney function at transplantation can benefit from early conversion to mammalian target of rapamycin inhibitor therapy (mTORi) compared with patients with late induction of mTORi-based therapy. MATERIALS AND METHODS: Between 2003 and 2008, therapy was changed to an mTORi-based regimen in 57 patients. Patients were divided into 4 groups: group 1, early conversion (≤3 months after orthotopic liver transplantation) to mTORi therapy, and with impaired perioperative renal function; group 2, early conversion to mTORi therapy, and with normal perioperative renal function; group 3, late conversion to mTORi therapy, and with impaired perioperative renal function; and group 4, late conversion to mTORi therapy, and with normal perioperative renal function. RESULTS: One month after conversion, the mean (SD) increase in calculated glomerular filtration rate in groups 1 (early conversion) and 3 (late conversion) was comparable: 8 (9) mL/min vs 7 (10) mL/min. At month 3, the increase in calculated glomerular filtration rate between groups 1 and 3 was significant (15 [11] mL/min vs 9 [15] mL/min; P = .04), an effect that persisted at month 6 (16 [12] mL/min vs 10 [12] mL/min; P = .05) and month 12 (22 [14] mL/min vs 12 [15] mL/min; P = .04). CONCLUSION: In liver transplant recipients with perioperatively impaired renal function, early conversion to mTORi therapy should be performed because this approach seems to be more effective in improving long-term renal function.
File Format	HTM / HTML
ISSN	00411345
Issue Number	7
Volume Number	42
e-ISSN	18732623
Journal	Transplantation Proceedings
Language	English
Publisher	Elsevier
Publisher Date	2010-09-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Transplantation__semicolon__medicine Immunosuppressive Agents Therapeutic Use Liver Transplantation Adverse Effects Immunology Tor Serine-threonine Kinases Antagonists & Inhibitors Adult Aged Creatinine Blood Everolimus Female Glomerular Filtration Rate Drug Effects Humans Kidney Diseases Etiology Liver Diseases Classification Surgery Male Middle Aged Sirolimus Analogs & Derivatives Journal Article
Content Type	Text
Resource Type	Article
Subject	Transplantation Surgery

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