NDLI: Stable expression of hypoxia-inducible factor-1 in human renal proximal tubular epithelial cells promotes epithelial to mesenchymal transition.

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Stable expression of hypoxia-inducible factor-1 in human renal proximal tubular epithelial cells promotes epithelial to mesenchymal transition.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Luo, L. Luo, G. Fang, Q. Sun, Z.
Description	Country affiliation: China Author Affiliation: Luo L ( Department of Research and Education, Guizhou Province People's Hospital, Guiyang, China.); Luo G ( Department of Urology Surgery, Guizhou Province People's Hospital, Guiyang, China.); Fang Q ( Department of Nursing, Guizhou Province People's Hospital, Guiyang, China.); Sun Z ( Department of Urology Surgery, Guizhou Province People's Hospital, Guiyang, China. Electronic address: szl7710@hotmail.com.)
Abstract	BACKGROUND: Late kidney allograft dysfunction is becoming a significant problem and tubular atrophy and interstitial fibrosis are main causes. It was reported that hypoxia could induce epithelial-mesenchymal transition (EMT) in renal tubular epithelial cells (TECs), and hypoxia-inducible factor-1 (HIF-1) is one of the important regulators of cellular adaptive to hypoxia. METHODS: In this study, we used an HIF-1 ΔODD-expressing adenovirus, which could stably and functionally express HIF-1 under normoxia conditions, and used a hypoxia/reoxygenation cell model to simulate ischemia/reperfusion (I/R) injury in vitro, to investigate the effect of HIF-1 on EMT-related gene expressions. RESULTS: Our results demonstrated that HIF-1 could significantly upregulate -smooth muscle actin expression, and reduced the E-cadherin expression in HK-2 cells during I/R injury. Moreover, miR-21 expression had a positive correlation with HIF-1 in this process. CONCLUSION: These results suggest that HIF-1 may promote the EMT development through regulating fibrotic gene expression during I/R injury in human renal TECs, and miR-21 could be among the important regulatory pathways in the process.
File Format	HTM / HTML
ISSN	00411345
Issue Number	1
Volume Number	46
e-ISSN	18732623
Journal	Transplantation Proceedings
Language	English
Publisher	Elsevier
Publisher Date	2014-01-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Transplantation__semicolon__medicine Epithelial-mesenchymal Transition Gene Expression Regulation Hypoxia-inducible Factor 1, Alpha Subunit Metabolism Kidney Tubules Cytology Actins Adenoviridae Genetics Cadherins Cell Line Graft Survival Humans Anoxia Pathology Kidney Kidney Transplantation Micrornas Muscle, Smooth Oxygen Rna Interference Reperfusion Injury Up-regulation Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Transplantation Surgery

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