NDLI: Immunologisk trombocytopeni--patofysiologi og behandling.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Ghanima, Waleed Holme, Pål André Tjønnfjord, Geir E.
Description	Country affiliation: Norway Author Affiliation: Ghanima W ( Hematologisk seksjon, Medisinsk avdeling, Sykehuset Østfold Fredrikstad, 1603 Fredrikstad, Norway. waleed.ghanima@so-hf.no)
Abstract	BACKGROUND: Immune thrombocytopenia (ITP) is caused by immune-mediated platelet destruction and reduced platelet production. The aim of this review article is to provide an updated overview of pathophysiology and new therapeutic modalities in ITP. MATERIAL AND METHODS: The article is based on literature identified through a non-systematic search in PubMed and our own clinical experience. RESULTS: ITP is diagnosed in patients with platelet count < 100 × 10(9)/l after excluding other causes of thrombocytopenia. Anti-platelet autoantibodies are important in the platelet destruction mechanism, but other important mechanisms have been identified in recent years. Patients with very low platelet count < 30 × 10(9)/l are particularly susceptible to bleeding complications. The goal of treatment so far has been to increase the platelet count to a level that reduces the risk of serious bleeding. Thrombopoietin receptor agonists are new therapeutic agents that target the thrombopoietin receptor to increase platelet production. These drugs are shown to be effective in treatment of ITP. INTERPRETATION: New knowledge about pathophysiological mechanisms, such as sub-optimal platelet production in ITP, has led to the development of new therapeutic options which focus on stimulation of platelet production.
File Format	HTM / HTML
ISSN	00292001
e-ISSN	08077096
Journal	Tidsskrift for Den norske legeforening
Issue Number	21
Volume Number	130
Language	Norwegian
Publisher	Norwegian Medical Association
Publisher Date	2010-11-04
Publisher Place	Norway
Access Restriction	Open
Subject Keyword	Discipline Medicine Purpura, Thrombocytopenic, Idiopathic Immunology Glucocorticoids Administration & Dosage Immunoglobulins, Intravenous Immunologic Factors Platelet Count Pregnancy Pregnancy Complications, Hematologic Physiopathology Therapy Receptors, Thrombopoietin Antagonists & Inhibitors Splenectomy
Alternative Title	Immune thrombocytopenia--pathophysiology and treatment
Content Type	Text
Resource Type	Article
Subject	Medicine

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