NDLI: Cardiac damage in acute organophosphate poisoning in rats: effects of atropine and pralidoxime.

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Cardiac damage in acute organophosphate poisoning in rats: effects of atropine and pralidoxime.

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Cardiac damage in acute organophosphate poisoning in rats: effects of atropine and pralidoxime.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Kose, Ataman Gunay, Nurullah Yildirim, Cuma Tarakcioglu, Mehmet Sari, Ibrahim Demiryurek, Abdullah T.
Description	Country affiliation: Turkey Author Affiliation: Kose A ( Department of Emergency Medicine, Faculty of Medicine, University of Gaziantep, 27310 Gaziantep, Turkey. akose@gantep.edu.tr)
Abstract	Anticholinesterase poisoning is an important health problem in our country, and a complete understanding of its underlying mechanisms is essential for the emergency physician. Thus, we aimed to investigate the cardiac biochemical parameters and mortality in dichlorvos-induced poisoning in rats. Rats were randomly divided into 5 groups as control (corn oil), dichlorvos, atropine, pralidoxime, and atropine+pralidoxime groups. Immunohistochemical analyses of apoptosis and inducible nitric oxide synthase showed no change in cardiac tissue for all of the groups. Serum cholinesterase levels were suppressed with dichlorvos, and these reductions were inhibited with atropine and/or pralidoxime pretreatment. Serum levels of creatine kinase, creatine kinase-MB, cardiac troponin I, myoglobin, and N-terminal probrain natriuretic peptide were not affected with poisoning. Malondialdehyde and glutathione levels were not statistically significant between the groups. Although serum nitric oxide levels in the dichlorvos group were lower than those in the control group, cardiac nitric oxide levels in the atropine+pralidoxime group were markedly higher than those in the dichlorvos group. Atropine, pralidoxime, and atropine+pralidoxime pretreatments markedly reduced the mortality. In conclusion, our results implied that measured cardiac markers especially N-terminal probrain natriuretic peptide may not contribute to the early (first 6 hours) diagnosis of cardiotoxicity in dichlorvos-induced poisoning in rats. These results also showed that acute dichlorvos administration did not cause significant cardiac damage, and oxidative stress does not play a marked role in dichlorvos-induced poisoning. Besides, cardiac nitric oxide may produce protective effect on myocardium with atropine+pralidoxime therapy in rats.
File Format	HTM / HTML
ISSN	07356757
Issue Number	2
Volume Number	27
e-ISSN	15328171
Journal	The American Journal of Emergency Medicine
Language	English
Publisher	Elsevier
Publisher Date	2009-02-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Emergency Discipline Medicine Antidotes Pharmacology Atropine Cholinesterase Inhibitors Poisoning Dichlorvos Heart Drug Effects Organophosphate Poisoning Pralidoxime Compounds Acute Disease Analysis Of Variance Animals Biological Markers Blood Immunohistochemistry In Situ Nick-end Labeling Male Nitric Oxide Random Allocation Rats Rats, Wistar Survival Rate Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Emergency Medicine

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