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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Miller, Michael A. Levsky, Marc E. Enslow, William Rosin, Alex |
| Description | Country affiliation: United States Author Affiliation: Miller MA ( Department of Emergency Medicine, Tripler Army Medical Center, Honolulu, Hawaii 96859, USA. michael.adam.miller@us.army.mil) |
| Abstract | UNLABELLED: Patients with headaches account for approximately 2% of all ED visits, with migraines being the most common defined primary headache syndrome. Our goals were to evaluate the efficacy of intravenous octreotide (OC) for the treatment of migraines, when compared to standard therapy with prochlorperazine. METHODS: The study was conducted as a double-blinded, randomized controlled trial. Each subject received either 100 microg of octreotide or 10 mg of prochlorperazine intravenously for a 2-minute period. RESULTS: Comparison of the change in median visual analog scale scores for 60 minutes demonstrated that octreotide was less effective at reducing pain (P = .03) and producing clinical success (P < .01). Restlessness consistent with akathisia was noted by 35% of the PC group and 8% of the OC group (P < .01). At 60 minutes, rescue medication was required by 48% of the patients in the OC group, whereas 10% of the PC group required such therapy (P < .01). All 44 patients were contacted for follow-up at 48 to 72 hours after enrollment. At that time, 10% of the prochlorperazine and 25% of the octreotide patients had experienced some headache recurrence (P = .1). CONCLUSION: Prochlorperazine was statistically superior to octreotide in clinical success rate and decrease in pain in migraine patients but caused more restlessness and sedation. |
| File Format | HTM / HTML |
| ISSN | 07356757 |
| Issue Number | 2 |
| Volume Number | 27 |
| e-ISSN | 15328171 |
| Journal | The American Journal of Emergency Medicine |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2009-02-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Emergency Discipline Medicine Dopamine Antagonists Therapeutic Use Migraine Disorders Drug Therapy Octreotide Prochlorperazine Adult Chi-square Distribution Administration & Dosage Double-blind Method Emergency Service, Hospital Female Humans Infusions, Intravenous Male Pain Measurement Treatment Outcome Journal Article Randomized Controlled Trial |
| Content Type | Text |
| Resource Type | Article |
| Subject | Emergency Medicine |
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