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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Xu, Jian Scheres, Ben |
| Description | Country affiliation: Netherlands Author Affiliation: Xu J ( Department of Molecular Cell Biology, Utrecht University, 3584 CH Utrecht, The Netherlands.) |
| Abstract | Vesicle trafficking is essential for the generation of asymmetries, which are central to multicellular development. Core components of the vesicle transport machinery, such as ADP-ribosylation factor (ARF) GTPases, have been studied primarily at the single-cell level. Here, we analyze developmental functions of the ARF1 subclass of the Arabidopsis thaliana multigene ARF family. Six virtually identical ARF1 genes are ubiquitously expressed, and single loss-of-function mutants in these genes reveal no obvious developmental phenotypes. Fluorescence colocalization studies reveal that ARF1 is localized to the Golgi apparatus and endocytic organelles in both onion (Allium cepa) and Arabidopsis cells. Apical-basal polarity of epidermal cells, reflected by the position of root hair outgrowth, is affected when ARF1 mutants are expressed at early stages of cell differentiation but after they exit mitosis. Genetic interactions during root hair tip growth and localization suggest that the ROP2 protein is a target of ARF1 action, but its localization is slowly affected upon ARF1 manipulation when compared with that of Golgi and endocytic markers. Localization of a second potential target of ARF1 action, PIN2, is also affected with slow kinetics. Although extreme redundancy precludes conventional genetic dissection of ARF1 functions, our approach separates different ARF1 downstream networks involved in local and specific aspects of cell polarity. |
| File Format | HTM / HTML |
| ISSN | 10404651 |
| e-ISSN | 1531298X |
| Journal | THE PLANT CELL ONLINE |
| Issue Number | 2 |
| Volume Number | 17 |
| Language | English |
| Publisher | American Society of Plant Biologists |
| Publisher Date | 2005-02-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Discipline Botany Arabidopsis Proteins Genetics Arabidopsis Dna-binding Proteins Gene Expression Regulation, Plant Plant Epidermis Cytology Transcription Factors Growth & Development Metabolism Cell Polarity Gtp Phosphohydrolases Gtp-binding Proteins Golgi Apparatus Green Fluorescent Proteins Microscopy, Fluorescence Multigene Family Onions Phenotype Physiology Plant Roots Plants, Genetically Modified Recombinant Fusion Proteins Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Plant Science |
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