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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Kleine-Vehn, Jürgen Dhonukshe, Pankaj Swarup, Ranjan Bennett, Malcolm Friml, Jirí |
| Description | Country affiliation: Germany Author Affiliation: Kleine-Vehn J ( Center for Molecular Biology of Plants, University of Tübingen, D-72076 Tübingen, Germany.) |
| Abstract | The directional flow of the plant hormone auxin mediates multiple developmental processes, including patterning and tropisms. Apical and basal plasma membrane localization of AUXIN-RESISTANT1 (AUX1) and PIN-FORMED1 (PIN1) auxin transport components underpins the directionality of intercellular auxin flow in Arabidopsis thaliana roots. Here, we examined the mechanism of polar trafficking of AUX1. Real-time live cell analysis along with subcellular markers revealed that AUX1 resides at the apical plasma membrane of protophloem cells and at highly dynamic subpopulations of Golgi apparatus and endosomes in all cell types. Plasma membrane and intracellular pools of AUX1 are interconnected by actin-dependent constitutive trafficking, which is not sensitive to the vesicle trafficking inhibitor brefeldin A. AUX1 subcellular dynamics are not influenced by the auxin influx inhibitor NOA but are blocked by the auxin efflux inhibitors TIBA and PBA. Furthermore, auxin transport inhibitors and interference with the sterol composition of membranes disrupt polar AUX1 distribution at the plasma membrane. Compared with PIN1 trafficking, AUX1 dynamics display different sensitivities to trafficking inhibitors and are independent of the endosomal trafficking regulator ARF GEF GNOM. Hence, AUX1 uses a novel trafficking pathway in plants that is distinct from PIN trafficking, providing an additional mechanism for the fine regulation of auxin transport. |
| File Format | HTM / HTML |
| ISSN | 10404651 |
| e-ISSN | 1531298X |
| Journal | THE PLANT CELL ONLINE |
| Issue Number | 11 |
| Volume Number | 18 |
| Language | English |
| Publisher | American Society of Plant Biologists |
| Publisher Date | 2006-11-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Discipline Botany Arabidopsis Proteins Metabolism Arabidopsis Indoleacetic Acids Membrane Transport Proteins Actins Drug Effects Brefeldin A Pharmacology Cytoskeleton Endosomes Fluorescence Recovery After Photobleaching Golgi Apparatus Guanine Nucleotide Exchange Factors Intracellular Membranes Models, Biological Phloem Cytology Plant Epidermis Protein Transport Sterols Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Plant Science |
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