NDLI: The Arabidopsis tail-anchored protein PEROXISOMAL AND MITOCHONDRIAL DIVISION FACTOR1 is involved in the morphogenesis and proliferation of peroxisomes and mitochondria.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Aung, Kyaw Hu, Jianping
Description	Country affiliation: United States Author Affiliation: Aung K ( Department of Energy, Michigan State University, East Lansing, Michigan 48824, USA.)
Abstract	Peroxisomes and mitochondria are multifunctional eukaryotic organelles that are not only interconnected metabolically but also share proteins in division. Two evolutionarily conserved division factors, dynamin-related protein (DRP) and its organelle anchor FISSION1 (FIS1), mediate the fission of both peroxisomes and mitochondria. Here, we identified and characterized a plant-specific protein shared by these two types of organelles. The Arabidopsis thaliana PEROXISOMAL and MITOCHONDRIAL DIVISION FACTOR1 (PMD1) is a coiled-coil protein tethered to the membranes of peroxisomes and mitochondria by its C terminus. Null mutants of PMD1 contain enlarged peroxisomes and elongated mitochondria, and plants overexpressing PMD1 have an increased number of these organelles that are smaller in size and often aggregated. PMD1 lacks physical interaction with the known division proteins DRP3 and FIS1; it is also not required for DRP3's organelle targeting. Affinity purifications pulled down PMD1's homolog, PMD2, which exclusively targets to mitochondria and plays a specific role in mitochondrial morphogenesis. PMD1 and PMD2 can form homo- and heterocomplexes. Organelle targeting signals reside in the C termini of these proteins. Our results suggest that PMD1 facilitates peroxisomal and mitochondrial proliferation in a FIS1/DRP3-independent manner and that the homologous proteins PMD1 and PMD2 perform nonredundant functions in organelle morphogenesis.
File Format	HTM / HTML
ISSN	10404651
e-ISSN	1531298X
DOI	10.1105/tpc.111.090142
Journal	THE PLANT CELL ONLINE
Issue Number	12
Volume Number	23
Language	English
Publisher	American Society of Plant Biologists
Publisher Date	2011-12-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Botany Arabidopsis Proteins Metabolism Arabidopsis Growth & Development Mitochondria Physiology Morphogenesis Peroxisomes Agrobacterium Tumefaciens Genetics Amino Acid Sequence Biological Markers Cell Proliferation Chromatography, Affinity Cloning, Molecular Membrane Proteins Microscopy, Electron, Transmission Mitochondrial Proteins Isolation & Purification Molecular Sequence Data Ultrastructure Plants, Genetically Modified Plasmids Protein Sorting Signals Sequence Homology, Amino Acid Tobacco Research Support, U.s. Gov't, Non-p.h.s.
Content Type	Text
Resource Type	Article
Subject	Cell Biology Plant Science

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The Arabidopsis Tail-Anchored Protein PEROXISOMAL AND MITOCHONDRIAL DIVISION FACTOR1 Is Involved in the Morphogenesis and Proliferation of Peroxisomes and Mitochondria [C] [W]

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The Arabidopsis tail-anchored protein PEROXISOMAL AND MITOCHONDRIAL DIVISION FACTOR1 is involved in the morphogenesis and proliferation of peroxisomes and mitochondria.

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The Arabidopsis Tail-Anchored Protein PEROXISOMAL AND MITOCHONDRIAL DIVISION FACTOR1 Is Involved in the Morphogenesis and Proliferation of Peroxisomes and Mitochondria [C] [W]

The protein encoded by oncogene 6b from Agrobacterium tumefaciens interacts with a nuclear protein of tobacco.

Peroxisomal tail-anchored proteins do not reach peroxisomes via ER, instead mitochondria can be involved

Identification of unique SUN-interacting nuclear envelope proteins with diverse functions in plants

An Arabidopsis GluTR binding protein mediates spatial separation of 5-aminolevulinic acid synthesis in chloroplasts.

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The Arabidopsis tail-anchored protein PEROXISOMAL AND MITOCHONDRIAL DIVISION FACTOR1 is involved in the morphogenesis and proliferation of peroxisomes and mitochondria.