NDLI: Two Distinct Domains of the UVR8 Photoreceptor Interact with COP1 to Initiate UV-B Signaling in Arabidopsis

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Yin, Ruohe Arongaus, Adriana B. Binkert, Melanie Ulm, Roman
Description	Country affiliation: Switzerland Author Affiliation: Yin R ( Department of Botany and Plant Biology, University of Geneva, Sciences III, CH-1211 Geneva 4, Switzerland.); Arongaus AB ( Department of Botany and Plant Biology, University of Geneva, Sciences III, CH-1211 Geneva 4, Switzerland.); Binkert M ( Department of Botany and Plant Biology, University of Geneva, Sciences III, CH-1211 Geneva 4, Switzerland.); Ulm R ( Department of Botany and Plant Biology, University of Geneva, Sciences III, CH-1211 Geneva 4, Switzerland roman.ulm@unige.ch.)
Abstract	UV-B photon reception by the Arabidopsis thaliana homodimeric UV RESISTANCE LOCUS8 (UVR8) photoreceptor leads to its monomerization and a crucial interaction with CONSTITUTIVELY PHOTOMORPHOGENIC1 (COP1). Relay of the subsequent signal regulates UV-B-induced photomorphogenesis and stress acclimation. Here, we report that two separate domains of UVR8 interact with COP1: the ß-propeller domain of UVR8 mediates UV-B-dependent interaction with the WD40 repeats-based predicted ß-propeller domain of COP1, whereas COP1 activity is regulated by interaction through the UVR8 C-terminal C27 domain. We show not only that the C27 domain is required for UVR8 activity but also that chemically induced expression of the C27 domain is sufficient to mimic UV-B signaling. We further show, in contrast with COP1, that the WD40 repeat proteins REPRESSOR OF UV-B PHOTOMORPHOGENESIS1 (RUP1) and RUP2 interact only with the UVR8 C27 domain. This coincides with their facilitation of UVR8 reversion to the ground state by redimerization and their potential to interact with UVR8 in a UV-B-independent manner. Collectively, our results provide insight into a key mechanism of photoreceptor-mediated signaling and its negative feedback regulation.
File Format	HTM / HTML
ISSN	10404651
e-ISSN	1531298X
DOI	10.1105/tpc.114.133868
Journal	THE PLANT CELL ONLINE
Issue Number	1
Volume Number	27
Language	English
Publisher	American Society of Plant Biologists
Publisher Date	2015-01-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Botany Arabidopsis Proteins Metabolism Arabidopsis Photoreceptors, Plant Ultraviolet Rays Gene Expression Regulation, Plant Protein Binding Signal Transduction Radiation Effects Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Cell Biology Plant Science

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Two Distinct Domains of the UVR8 Photoreceptor Interact with COP1 to Initiate UV-B Signaling in Arabidopsis [OPEN]

The UV-B photoreceptor UVR8: from structure to physiology.

UV-B, UV-A, and blue light signal transduction pathways interact synergistically to regulate chalcone synthase gene expression in Arabidopsis.

In Vivo Function of Tryptophans in the Arabidopsis UV-B Photoreceptor UVR8

C-terminal region of the UV-B photoreceptor UVR8 initiates signaling through interaction with the COP1 protein

Arabidopsis B-box transcription factors BBX20-22 promote UVR8 photoreceptor-mediated UV-B responses.

Reversion of the Arabidopsis UV-B photoreceptor UVR8 to the homodimeric ground state

The molecular mechanism of the UVR8 UV-B photoreceptor.

Perception of UV-B by the Arabidopsis UVR8 protein.

Two Distinct Domains of the UVR8 Photoreceptor Interact with COP1 to Initiate UV-B Signaling in Arabidopsis

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Two Distinct Domains of the UVR8 Photoreceptor Interact with COP1 to Initiate UV-B Signaling in Arabidopsis [OPEN]

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