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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Hu, Feng Zhang, Yan Chen, Guangcun Li, Chunyan Wang, Qiangbin |
| Description | Country affiliation: China Author Affiliation: Hu F ( Key Laboratory of Nano-Bio Interface, Division of Nanobiomedicine and i-Lab, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou, 215123, China.) |
| Abstract | In this work, a novel type of nanomedical platform, the double-walled Au $nanocage/SiO_{2}$ nanorattle, is successfully fabricated by combining two “hollow-excavated strategies”—galvanic replacement and “surface-protected etching”. The rational design of double-walled nanostructure based on gold nanocages (AuNCs) and hollow $SiO_{2}$ shells functionalized respectively with p-aminothiophenol (pATP) and Tat peptide simultaneously renders the nanoplatforms three functionalities: 1) the whole nanorattle serves as a high efficient drug carrier thanks to the structural characteristics of AuNC and $SiO_{2}$ shell with hollow interiors and porous walls; 2) the AuNC with large electromagnetic enhancement acts as a sensitive surface-enhanced Raman scattering (SERS) substrate to track the internalization process of the nanorattles by human MCF-7 breast cancer cells, as well as an efficient photothermal transducer for localized hyperthermia cancer therapy due to the strong near-infrared absorption; 3) Tat-functionalized $SiO_{2}$ shell not only improves biocompatibility and cell uptake efficiency resulting in enhanced anticancer efficacy but also prevents the AuNCs from aggregation and provides the stability of AuNCs so that the SERS signals can be used for cell tracking in high fidelity. The reported chemistry and the designed nanostructures should inspire more interesting nanostructures and applications. |
| File Format | HTM / HTML |
| ISSN | 16136810 |
| Issue Number | 8 |
| Volume Number | 11 |
| e-ISSN | 16136829 |
| Journal | Small |
| Language | English |
| Publisher | Wiley-VCH |
| Publisher Date | 2015-02-25 |
| Publisher Place | Germany |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Nanotechnology Drug Delivery Systems Gold Chemistry Metal Nanoparticles Nanotechnology Methods Phototherapy Silicon Dioxide Aniline Compounds Antineoplastic Agents Biocompatible Materials Calibration Electromagnetic Radiation Humans Hydrogen-ion Concentration Mcf-7 Cells Microscopy, Electron, Transmission Neoplasms Metabolism Photochemistry Spectrum Analysis, Raman Sulfhydryl Compounds Tat Gene Products, Human Immunodeficiency Virus Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Chemistry Nanoscience and Nanotechnology Medicine Biomaterials Engineering Biotechnology |
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