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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Lee, Wong Cheng Lim, Candy Haley Su, Chenliang Loh, Kian Ping Lim, Chwee Teck |
| Description | Country affiliation: Singapore Author Affiliation: Lee WC ( Department of Biomedical Engineering and Department of Mechanical Engineering, National University of Singapore, Singapore, 117575, Singapore) |
| Abstract | Graphene-based nanomaterials are increasingly being explored for use as biomaterials for drug delivery and tissue engineering applications due to their exceptional physicochemical and mechanical properties. However, the two-dimensional nature of graphene makes it difficult to extend its applications beyond planar tissue culture. Here, graphene-cell biocomposites are used to pre-concentrate growth factors for chondrogenic differentiation. Bone marrow-derived mesenchymal stem cells (MSCs) are assembled with graphene flakes in the solution to form graphene-cell biocomposites. Increasing concentrations of graphene (G) and porous graphene oxide (pGO) are found to correlate positively with the extent of differentiation. However, beyond a certain concentration, especially in the case of graphene oxide, it will lead to decreased chondrogenesis due to increased diffusional barrier and cytotoxic effects. Nevertheless, these findings indicate that both G and pGO could serve as effective pre-concentration platforms for the construction of tissue-engineered cartilage and suspension-based cultures in vitro. |
| File Format | HTM / HTML |
| ISSN | 16136810 |
| Issue Number | 8 |
| Volume Number | 11 |
| e-ISSN | 16136829 |
| Journal | Small |
| Language | English |
| Publisher | Wiley-VCH |
| Publisher Date | 2015-02-25 |
| Publisher Place | Germany |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Nanotechnology Chondrocytes Cytology Chondrogenesis Graphite Chemistry Biocompatible Materials Blood Proteins Bone Marrow Cells Cell Differentiation Cell Survival Cells, Cultured Collagen Humans Nanostructures Nanotechnology Methods Oxides Porosity Spectrophotometry Stress, Mechanical Tissue Engineering Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Chemistry Nanoscience and Nanotechnology Medicine Biomaterials Engineering Biotechnology |
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