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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Urio, Loveness John Mohamed, Mohamed Ally Mghamba, Janneth Abade, Ahmed Aboud, Said |
| Spatial Coverage | Tanzania |
| Description | Country affiliation: Tanzania Author Affiliation: Urio LJ ( Tanzania Field Epidemiology and Laboratory Training Program, Tanzania.); Mohamed MA ( Tanzania Field Epidemiology and Laboratory Training Program, Tanzania ); Mghamba J ( Tanzania Field Epidemiology and Laboratory Training Program, Tanzania ); Abade A ( Tanzania Field Epidemiology and Laboratory Training Program, Tanzania.); Aboud S ( Mirobiology and Immunology, Muhimbili University of Health and Allied Sciences, Ho, Ghana.) |
| Abstract | INTRODUCTION: The aim of this study was to evaluate the performance of Enzygnost HIV Integral II antigen/antibody combination ELISAs in order to formulate HIV ELISA testing algorithms for the Ministry of Health and Social Welfare, Tanzania. METHODS: This was a laboratory-based evaluation of Enzygnost HIV Integral II Antibody/ Antigen, Murex HIV antigen/antibody and Vironostika HIV Uniform II antigen/antibody conducted between October 2011 and May 2012. RESULTS: A total of 600 blood samples were included in the evaluation. A total of 209/596 (35.1%) serum samples were confirmed HIV positive. Of these, the prevalence of HIV infection was 2.3% (3/130), 2.3% (3/127), 2.2% (3/139) and 100% (200/200) for VCT clients, ANC attendees, blood donors and CTC patients, respectively. Three hundred and eighty seven (64.9%) were HIV negative samples. Sensitivity was 100% (95% CI; 98.3-100%) for all the three HIV ELISAs. The specificity for the Enzygnost HIV Integral II and Murex was 100% (95% CI; 99.1-100%). The final specificity at repeat testing was 99.5% (95% CI; 98.2-99.9%) for Vironostika. Enzygnost HIV Integral II detected HIV infection seven days since first bleed. CONCLUSION: Initial testing using either Vironostika or Murex HIV antigen/antibody combination ELISA followed by testing of reactive samples on the Enzygnost HIV Integral II gave a sensitivity and specificity of 100% with reduced window period. Combination of two HIV antigen/antibody combination ELISAs can be used as an alternative confirmatory testing strategy for screening of donated blood at the National and Zonal blood transfusion centres and in lab diagnosis of HIV infection. |
| File Format | HTM / HTML |
| e-ISSN | 19378688 |
| DOI | 10.11604/pamj.2015.20.196.4934 |
| Journal | Pan African Medical Journal |
| Volume Number | 20 |
| Language | English |
| Publisher | African Field Epidemiology Network |
| Publisher Date | 2015-01-01 |
| Publisher Place | Uganda |
| Access Restriction | Open |
| Subject Keyword | Discipline Medicine Aids Serodiagnosis Enzyme-linked Immunosorbent Assay Hiv Antibodies Blood Hiv Infections Diagnosis Algorithms Blood Donors Cross-sectional Studies Hiv Antigens Epidemiology Sensitivity And Specificity Tanzania |
| Content Type | Text |
| Resource Type | Article |
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