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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Aarab, N. Pampanin, D. M. Naevdal, A. Oysaed, K. B. Gastaldi, L. Bechmann, R. K. |
| Spatial Coverage | Norway |
| Description | Country affiliation: Norway Author Affiliation: Aarab N ( International Research Institute of Stavanger (IRIS) - Biomiljø, Mekjarvik 12 N-4070 Randaberg, Norway. nadia.aarab@iris.no) |
| Abstract | Histopathological characteristics of specific organs express condition, and represent time-integrated impacts on the organism stemming from alterations at lower levels of biological organisation. As integrative parameters, histochemical investigations have proved to be sensitive tools to detect effects of chemical compounds. The objective of this study was to determine changes in the tissues of mussels collected at a PAH contaminated site compared to a reference site using histopathological and histochemical parameters: lipofuscin (LF) accumulation in mussel digestive gland, and lysosomal membrane stability (LMS), and using additional information provided by body burden analysis to compare the sensitivity of these parameters. The histochemical measurements for both LF and LMS gave a clear indication of a high level of stress in animals from the PAH contaminated site. This LF accumulation in lysosomes is the result of peroxidation of autophagocytosed proteins associated with protein aggregates and oxidatively damaged organelles. These measurements were able to detect the effects of PAHs, and showed a strong relationship with the body burden results. |
| File Format | HTM / HTML |
| ISSN | 0025326X |
| Issue Number | 6-12 |
| Volume Number | 57 |
| e-ISSN | 18793363 |
| Journal | Marine Pollution Bulletin |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2008-01-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Biology Aluminum Industrial Waste Mytilus Edulis Drug Effects Polycyclic Hydrocarbons, Aromatic Toxicity Water Pollutants, Chemical Animals Digestive System Pathology Lipofuscin Analysis Norway Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pollution Aquatic Science Oceanography |
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