NDLI: CYP4 mRNA expression in marine polychaete Perinereis aibuhitensis in response to petroleum hydrocarbon and deltamethrin.

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CYP4 mRNA expression in marine polychaete Perinereis aibuhitensis in response to petroleum hydrocarbon and deltamethrin.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Chen, Xue Zhou, Yibing Yang, Dazuo Zhao, Huan Wang, Lili Yuan, Xiutang
Description	Country affiliation: China Author Affiliation: Chen X ( Key Laboratory of Marine Bio-resources Restoration and Habitat Reparation in Liaoning Province, Dalian Ocean University, Dalian 116023, China.)
Abstract	A CYP4 cDNA was cloned and characterized to identify the relationship between persistent organic pollutants and stress response in marine polychaete Perinereis aibuhitensis. The full length of PaCYP4 cDNA is 1857bp and encodes 481 amino acids. The deduced amino acid sequence showed 73% identity with CYP4BB1 from polychaete Nereis virens and shared high homology to other known CYP4 sequences. The expression level of PaCYP4 under petroleum hydrocarbon (PH) and deltamethrin (DM) exposure was detected using Real-time PCR. PH and combined toxicity treatments elevated the mRNA level of PaCYP4 in a dose- and time-dependent manner. The mRNA transcripts of PaCYP4 increased at the beginning of DM exposure and then eventually decreased, and the expression level of PaCYP4 down-regulated with increasing concentration of DM. CYP4 in P. aibuhitensis plays an important role in the metabolism of petroleum hydrocarbon and organochlorine pesticide.
File Format	HTM / HTML
ISSN	0025326X
Issue Number	9
Volume Number	64
e-ISSN	18793363
Journal	Marine Pollution Bulletin
Language	English
Publisher	Elsevier
Publisher Date	2012-09-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Biology Aryl Hydrocarbon Hydroxylases Genetics Hydrocarbons Toxicity Nitriles Petroleum Polychaeta Pyrethrins Rna, Messenger Metabolism Water Pollutants, Chemical Amino Acid Sequence Animals Molecular Sequence Data Drug Effects Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Pollution Aquatic Science Oceanography

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CYP4 mRNA expression in marine polychaete Perinereis aibuhitensis in response to petroleum hydrocarbon and deltamethrin.

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CYP4 mRNA expression in marine polychaete Perinereis aibuhitensis in response to petroleum hydrocarbon and deltamethrin.