NDLI: Ultra high performance liquid chromatography with tandem mass spectrometry method for the determination of tetrandrine and fangchinoline in rat plasma after oral administration of Fangji Huangqi Tang and Stephania tetrandra S. Moore extracts.

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Ultra high performance liquid chromatography with tandem mass spectrometry method for the determination of tetrandrine and fangchinoline in rat plasma after oral administration of Fangji Huangqi Tang and Stephania tetrandra S. Moore extracts.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Wang, Xiaoli Liu, Xiao Cai, Hao Pei, Ke Cao, Gang Xu, Xiaoyan Shi, Fa Cai, Baochang
Description	Author Affiliation: Wang X ( College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, P. R. China)
Abstract	A rapid, sensitive, and reliable analytical method based on ultra high performance liquid chromatography with tandem mass spectrometry has been developed for the simultaneous determination of fangchinoline and tetrandrine in rat plasma. Plasma samples were pretreated by protein precipitation with acetonitrile. The analysis was performed on a C18 reversed-phase ultra high performance liquid chromatography column (2.1 mm × 100 mm, 3.5 µm, Agilent), and the flow rate was set at 0.4 mL/min. Under the experimental conditions, extraction recoveries from plasma were 68.1-72.8% for fangchinoline and 69.2-76.5% for tetrandrine. The plasma concentrations of tetrandrine and fangchinoline in rats at assigned time points were all successfully detected through exactly validated method. Good linearities were obtained in the range of 0.92-184 ng/mL for tetrandrine and in the range of 0.83-166 ng/mL for fangchinoline. The intra- and interday precisions for both analytes were within 11.1% and the accuracies were within the range of -10.7 to 11.3%. The developed method was then successfully applied to investigate the pharmacokinetic properties of these two alkaloids after oral administration of Stephania tetrandra S. Moore extracts and Fangji Huangqi Tang. The comparative results provided a meaningful basis for a better understanding of the practical value of the compatibility theory of traditional Chinese medicine in the clinic.
File Format	HTM / HTML
ISSN	16159306
Issue Number	8
Volume Number	38
e-ISSN	16159314
Journal	Journal of Separation Science
Language	English
Publisher	Wiley-VCH
Publisher Date	2015-05-01
Publisher Place	Germany
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Analytical Discipline Chemistry Benzylisoquinolines Blood Drugs, Chinese Herbal Chemistry Acetonitriles Administration, Oral Animals Area Under Curve Calibration Chromatography, High Pressure Liquid Limit Of Detection Male Plant Extracts Rats Rats, Sprague-dawley Reproducibility Of Results Tandem Mass Spectrometry Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Analytical Chemistry Filtration and Separation

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