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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Asadi, Mohammad Dadfarnia, Shayessteh Haji Shabani, Ali Mohammad Abbasi, Bijan |
| Description | Country affiliation: Iran Author Affiliation: Asadi M ( Department of Chemistry, Faculty of Science, Yazd University, Yazd, Iran.); Dadfarnia S ( Khorassan Research Institute for Food Science and Technology, Mashhad, Iran.); Haji Shabani AM ( Department of Chemistry, Faculty of Science, Yazd University, Yazd, Iran.); Abbasi B ( Department of Chemistry, Faculty of Science, Yazd University, Yazd, Iran.) |
| Abstract | A novel and simple method based on solidified floating organic drop microextraction followed by high-performance liquid chromatography with ultraviolet detection has been developed for simultaneous preconcentration and determination of phenobarbital, lamotrigine, and phenytoin in human plasma and urine samples. Factors affecting microextraction efficiency such as the type and volume of the extraction solvent, sample pH, extraction time, stirring rate, extraction temperature, ionic strength, and sample volume were optimized. Under the optimum conditions (i.e. extraction solvent, 1-undecanol (40 µL); sample pH, 8.0; temperature, 25°C; stirring rate, 500 rpm; sample volume, 7 mL; potassium chloride concentration, 5% and extraction time, 50 min), the limits of detection for phenobarbital, lamotrigine, and phenytoin were 1.0, 0.1, and 0.3 µg/L, respectively. Also, the calibration curves for phenobarbital, lamotrigine, and phenytoin were linear in the concentration range of 2.0-300.0, 0.3-200.0, and 1.0-200.0 µg/L, respectively. The relative standard deviations for six replicate extractions and determinations of phenobarbital, lamotrigine, and phenytoin at 50 µg/L level were less than 4.6%. The method was successfully applied to determine phenobarbital, lamotrigine, and phenytoin in plasma and urine samples. |
| File Format | HTM / HTML |
| ISSN | 16159306 |
| Issue Number | 14 |
| Volume Number | 38 |
| e-ISSN | 16159314 |
| Journal | Journal of Separation Science |
| Language | English |
| Publisher | Wiley-VCH |
| Publisher Date | 2015-07-01 |
| Publisher Place | Germany |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Analytical Discipline Chemistry Phenobarbital Blood Urine Phenytoin Triazines Chromatography, High Pressure Liquid Humans Hydrogen-ion Concentration Limit Of Detection Liquid Phase Microextraction Organic Chemicals Osmolar Concentration Reproducibility Of Results Solid Phase Microextraction Solvents Temperature Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Analytical Chemistry Filtration and Separation |
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