NDLI: Histopathologic and Histomorphometric Analysis of Irradiation Injury in Bone and the Surrounding Soft Tissues of the Jaws.

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Histopathologic and Histomorphometric Analysis of Irradiation Injury in Bone and the Surrounding Soft Tissues of the Jaws.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Curi, Marcos Martins Cardoso, Camila Lopes de Lima, Heliton Gustavo Kowalski, Luiz Paulo Martins, Manoela Domingues
Description	Country affiliation: Brazil Author Affiliation: Curi MM ( Chair, Department of Stomatology, Hospital Santa Catarina, São Paulo, Brazil); Cardoso CL ( Professor, Department of Oral Surgery, University Sagrado Coração, Bauru, Brazil.); de Lima HG ( PhD Student, Department of Oral Medicine, Area of Pathology, Bauru School of Dentistry, University of São Paulo, Bauru, Brazil. Electronic address: heliton.lima@usp.br.); Kowalski LP ( Chair, Department of Head and Neck Surgery and Otorhinolaryngology, Cancer Hospital A.C. Camargo, São Paulo, Brazil.); Martins MD ( Professor, Department of Oral Pathology, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.)
Abstract	PURPOSE: Surgery of irradiated tissue has an increased complication rate because of the development of hypovascular, hypocellular, and hypoxic tissue. This study was undertaken to perform histopathologic and histomorphometric analyses of irradiation tissue injury in bone and the surrounding soft tissues. MATERIAL AND METHODS: The histopathologic findings of 40 human mandibular bones and the surrounding soft tissue specimens obtained from different patients who underwent surgical procedures for treatment of osteoradionecrosis of the jaws were reviewed. RESULTS: Histopathologic examination showed 7 processes in the following order of appearance: hyperemia, endarteritis, thrombosis, cell loss, hypovascularity, increase of fat in the bone marrow cavity, and fibrosis. Histomorphometric analysis showed significant hypocellularity (P = .007), hypovascularity (P < .001), and fibrosis (P < .001) in irradiated specimens compared with control specimens. CONCLUSION: These results showed that radiation injuries affect the bone and surrounding soft tissues. However, the irradiation-induced injuries, such as cellular loss (hypocellularity) and fibrosis, were more expressive in bone tissue than in the surrounding soft tissues.
File Format	HTM / HTML
ISSN	02782391
Issue Number	1
Volume Number	74
e-ISSN	15315053
Journal	Journal of Oral and Maxillofacial Surgery
Language	English
Publisher	Elsevier
Publisher Date	2016-01-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Medicine__semicolon__otorhinolaryngology__semicolon__surgery Mandibular Diseases Pathology Osteoradionecrosis Periodontium Radiation Effects Adipose Tissue Antigens, Cd34 Analysis Bone Marrow Cell Death Endarteritis Endothelium, Vascular Fibrosis Head And Neck Neoplasms Radiotherapy Humans Hyperemia Microvessels Radiotherapy Dosage Radiotherapy, High-energy Methods Thrombosis Comparative Study Journal Article
Content Type	Text
Resource Type	Article
Subject	Oral Surgery Otorhinolaryngology Surgery

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