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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Olsen, Jesper J. Skov, Jane Ingerslev, Janne Thorn, Jens J. Pinholt, Else M. |
| Description | Author Affiliation: Olsen JJ ( PhD Candidate, Department of Oral and Maxillofacial Surgery, Hospital of South West Denmark, Esbjerg, Denmark); Skov J ( Senior Researcher, Unit for Thrombosis Research, Institute of Public Health, University of Southern Denmark, Department of Clinical Biochemistry, Hospital of South West Denmark, Esbjerg, Denmark.); Ingerslev J ( Consultant, Department of Oral and Maxillofacial Surgery, Hospital of South West Denmark, Esbjerg, Denmark.); Thorn JJ ( Consultant, Department of Oral and Maxillofacial Surgery, Hospital of South West Denmark, Esbjerg, Denmark.); Pinholt EM ( Professor and Consultant, Department of Oral and Maxillofacial Surgery, Hospital of South West Denmark, Esbjerg, Denmark) |
| Abstract | PURPOSE: The objective of the present study was to evaluate the efficacy of hemostatic adjuncts on intraoperative blood loss (IOB) in orthognathic surgery (OS) detected by randomized controlled trials (RCTs) of the highest quality. MATERIALS AND METHODS: A search of the Medline, Cochrane, Embase, and Web of Science databases was performed in January 2015, and the risk of bias was assessed using the Jadad and Delphi scales. The predictor variable was the hemostatic measures, and the main outcome variable was the total IOB volume. The secondary outcome variables were the hemoglobin and hematocrit and operating time. This review is registered at PROSPERO (CRD42014014840). RESULTS: Eleven trials were included for review. The individual trials demonstrated the effects on IOB from hypotensive anesthetic regimens, the use of aprotinin, and the herbal medicine Yunnan Baiyao. Six studies of tranexamic acid (TXA), with 288 patients, were suitable for a meta-analysis of continuous data. TXA reduced IOB by an average of 171 mL (95% confidence interval [CI] -230 to -112; P < .00001). Its topical use yielded similarly significant results (mean difference -197, 95% CI -319 to -76; P < .001). A subgroup analysis showed a decreased operating time in the TXA groups by an average of 15 minutes (mean difference -14.78, 95% CI -22.21 to -7.35; P < .0001). CONCLUSIONS: Efficient hemostatic adjuncts exist for OS. Our meta-analysis showed that TXA significantly reduces IOB by an average of one third, regardless of whether it was given intravenously (IV) or applied topically. Additional RCTs are needed to confirm the effect of topical TXA in OS, and larger studies of intravenous administration are needed before any routine recommendations. No hemostatic effect of hypotensive anesthesia was found, mainly owing to imprecise descriptions of the blinding procedures. Transparent and uniform trial reporting is thus encouraged in future studies. |
| File Format | HTM / HTML |
| ISSN | 02782391 |
| Issue Number | 1 |
| Volume Number | 74 |
| e-ISSN | 15315053 |
| Journal | Journal of Oral and Maxillofacial Surgery |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2016-01-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Medicine__semicolon__otorhinolaryngology__semicolon__surgery Blood Loss, Surgical Prevention & Control Hemostatics Therapeutic Use Orthognathic Surgical Procedures Methods Hematocrit Hemoglobins Analysis Humans Operative Time Randomized Controlled Trials As Topic Tranexamic Acid Treatment Outcome Journal Article Meta-analysis Review |
| Content Type | Text |
| Resource Type | Article |
| Subject | Oral Surgery Otorhinolaryngology Surgery |
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