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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Yoshizawa, Masato Jeffery, William R. |
| Description | Country affiliation: United States Author Affiliation: Yoshizawa M ( Department of Biology, University of Maryland, College Park, MD 20742, USA. yossy@umd.edu) |
| Abstract | The blind cavefish Astyanax mexicanus undergoes bilateral eye degeneration during embryonic development. Despite the absence of light in the cave environment, cavefish have retained a structurally intact pineal eye. We show here that contrary to visual degeneration in the bilateral eyes, the cavefish pineal eye has conserved the ability to detect light. Larvae of two different Astyanax cavefish populations and the con-specific sighted surface-dwelling form (surface fish) respond similarly to light dimming by shading the pineal eye. As a response to shading, cavefish larvae swim upward vertically. This behavior resembles that of amphibian tadpoles rather than other teleost larvae, which react to shadows by swimming downward. The shadow response is highest at 1.5-days post-fertilization (d.p.f.), gradually diminishes, and is virtually undetectable by 7.5 d.p.f. The shadow response was substantially reduced after surgical removal of the pineal gland from surface fish or cavefish larvae, indicating that it is based on pineal function. In contrast, removal of one or both bilateral eye primordia did not affect the shadow response. Consistent with its light detecting capacity, immunocytochemical studies indicate that surface fish and cavefish pineal eyes express a rhodopsin-like antigen, which is undetectable in the degenerating bilateral eyes of cavefish larvae. We conclude that light detection by the pineal eye has been conserved in cavefish despite a million or more years of evolution in complete darkness. |
| File Format | HTM / HTML |
| ISSN | 00220949 |
| e-ISSN | 14779145 |
| DOI | 10.1242/jeb.012864 |
| Journal | Journal of Experimental Biology |
| Issue Number | Pt 3 |
| Volume Number | 211 |
| Language | English |
| Publisher | The Company of Biologists |
| Publisher Date | 2008-02-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | Open |
| Subject Keyword | Discipline Biology Blindness Eye Physiology Pineal Gland Animals Veterinary Larva Surgery Rhodopsin Metabolism Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't Research Support, U.s. Gov't, Non-p.h.s. |
| Content Type | Text |
| Resource Type | Article |
| Subject | Physiology Medicine Aquatic Science Molecular Biology Animal Science and Zoology Ecology, Evolution, Behavior and Systematics Insect Science |
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