NDLI: Anti-mycobacterial activity of five plant species used as traditional medicines in the Western Cape Province (South Africa).

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Anti-mycobacterial activity of five plant species used as traditional medicines in the Western Cape Province (South Africa).

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Bamuamba, Kapinga Gammon, David W. Meyers, Paul Dijoux-Franca, Marie-Genevieve Scott, Gillian
Spatial Coverage	South Africa
Description	Country affiliation: South Africa Author Affiliation: Bamuamba K ( Department of Molecular and Cell Biology, University of Cape Town, Rondebosch 7701, South Africa.)
Abstract	ETHNOPHARMACOLOGICAL RELEVANCE: Five plants used in traditional medicine in the Western Cape Province of South Africa, have been investigated for anti-mycobacterial activity: Olea capensis, Tulbaghia alliacea, Dittrichia graveolens, Leysera gnaphalodes and Buddleja saligna. AIM OF THE STUDY: The aim was to assess antimycobacterial activity in plants used in treatment of symptoms of TB, and through activity-guided fractionation of extracts to isolate compounds or mixtures with potential as anti-TB drug leads. MATERIALS AND METHODS: Extracts and derived fractions were assayed against strains of Escherichia coli, Staphylococcus aureus, and Mycobacterium aurum A+. Isolated pure compounds were further tested against Mycobacterium species M. avium ATCC 25291, M. scrofulaceum ATCC 19981, M. microti ATCC 19422 and Mtb H37Rv, and for cytotoxicity against Chinese hamster ovarian cells. RESULTS: Extracts of B. saligna and L. gnaphaloides exhibited significant anti-mycobacterial activity, primarily associated with the presence of non-cytotoxic triterpenoids oleanolic acid in B. saligna and both oleanolic and ursolic acids in L. gnaphaloides. CONCLUSIONS: Anti-mycobacterial activity of extracts of selected plants is consistent with their traditional use. The identification of oleanolic and ursolic acids in these plants, and verification of their activity, underlines the potential for exploring structure-activity relationships of derivatives of these ubiquitous triterpenoids.
File Format	HTM / HTML
ISSN	03788741
Issue Number	2
Volume Number	117
e-ISSN	18727573
Journal	Journal of Ethnopharmacology
Language	English
Publisher	Elsevier
Publisher Date	2008-05-08
Publisher Place	Ireland
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Ethnopharmacology Anti-bacterial Agents Pharmacology Medicine, African Traditional Mycobacterium Drug Effects Plants, Medicinal Chemistry Cell Line, Tumor Chromatography, Thin Layer Colorimetry Drug Screening Assays, Antitumor Humans Magnetic Resonance Spectroscopy Microbial Sensitivity Tests Plant Extracts South Africa Spectrometry, Mass, Electrospray Ionization Tetrazolium Salts Thiazoles Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Drug Discovery Pharmacology

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