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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Jin, Xiaoying Shen, Gang Gao, Feng Zheng, Xuesheng Xu, Xiaoyan Shen, Fang Li, Gu Gong, Jiangbiao Wen, Liang Yang, Xiaofeng Bie, Xiaodong |
| Description | Country affiliation: China Author Affiliation: Jin X ( Department of Traditional Chinese Medicine, Second Affiliated Hospital, School of Medicine, Zhejiang University, #88 Jiefang Road, Hangzhou 310009, China.) |
| Abstract | ETHNOPHARMACOLOGICAL RELEVANCE: ShuXueTong injection is a traditional Chinese drug designed to treat the patients of 'blood stasis and stagnation (yu xue yu zhi)', including subacute brain trauma. However, the mechanism of the therapeutic effect of ShuXueTong on traumatic brain injury is unknown yet. AIM OF THE STUDY: We hypothesized that ShuXueTong may promote the brain wound healing by facilitating angiogenesis. Thus this study was designed to explore this hypothesis. MATERIALS AND METHODS: By means of microvessel count, Western blotting, immunocytochemistry, methyl thiazolyl tetrazolium assay and etc., the effect of ShuXueTong on the angiogenesis of brain wound was studied and then its influence on the VEGF/VEGFR-2 pathway were explored. RESULTS: ShuXueTong facilitates angiogenesis in the brain wound and improves the neurological function of the traumatized rats. VEGF expression in the lesion was elevated due to ShuXueTong induction. The in vitro experiment revealed VEGFR-2 and SRF expression in the endothelial cells were enhanced when exposed to ShuXueTong for merely 1d. Moreover, ShuXueTong promoted the endothelial cell proliferation via the VEGF/VEGFR-2 pathway. CONCLUSIONS: The mechanism of the therapeutic effect of ShuXueTong on traumatic brain injury lies at least partly in the enhanced angiogenesis in the lesion. |
| File Format | HTM / HTML |
| ISSN | 03788741 |
| Issue Number | 3 |
| Volume Number | 117 |
| e-ISSN | 18727573 |
| Journal | Journal of Ethnopharmacology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2008-05-22 |
| Publisher Place | Ireland |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Ethnopharmacology Angiogenesis Modulating Agents Pharmacology Brain Injuries Drug Therapy Drugs, Chinese Herbal Neovascularization, Physiologic Drug Effects Wound Healing Animals Pathology Capillaries Endothelium, Vascular Enzymology Male Medicine, Chinese Traditional Motor Activity Physiology Paralysis Etiology Rats Rats, Sprague-dawley Receptors, Vascular Endothelial Growth Factor Metabolism Serum Response Factor Biosynthesis Tetrazolium Salts Thiazoles Vascular Endothelial Growth Factor A Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Drug Discovery Pharmacology |
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