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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Olsen, Helle T. Stafford, Gary I. Van Staden, Johannes Christensen, Søren B. Jäger, Anna K. |
| Description | Country affiliation: Denmark Author Affiliation: Olsen HT ( Department of Medicinal Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, 2 Universitetsparken, 2100 Copenhagen O, Denmark.) |
| Abstract | AIMS OF THE STUDY: To isolate the compound(s) responsible for the MAO-inhibitory activity. MATERIALS AND METHODS: Six extracts of varying polarity of Mentha aquatica L. were tested in a photometric peroxidase linked MAO bioassay. The 70% ethanol extract had highest inhibitory activity. (S)-Naringenin was isolated from the extract by bioassay guided fractionation on VLC and preparative TLC. The structure of the compound was determined by (1)H, (13)C and (13)C-DEPT NMR and optical rotation. RESULTS: The IC(50) values for MAO inhibition by naringenin were 342+/-33 microM for the rat liver mitochondrial fraction, 955+/-129 microM for MAO-A and 288+/-18 microM for MAO-B. CONCLUSIONS: The content of naringenin in Mentha aquatica might explain its use in traditional medicine for depression-like conditions. |
| File Format | HTM / HTML |
| ISSN | 03788741 |
| Issue Number | 3 |
| Volume Number | 117 |
| e-ISSN | 18727573 |
| Journal | Journal of Ethnopharmacology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2008-05-22 |
| Publisher Place | Ireland |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Ethnopharmacology Flavanones Isolation & Purification Pharmacology Mentha Chemistry Monoamine Oxidase Inhibitors Animals Chromatography, Liquid Chromatography, Thin Layer In Vitro Techniques Magnetic Resonance Spectroscopy Male Mitochondria, Liver Drug Effects Enzymology Plant Extracts Plant Leaves Rats Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Drug Discovery Pharmacology |
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