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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Cheng, Brian Chi-Yan Ma, Xiao-Qing Kwan, Hiu-Yee Tse, Kai-Wing Cao, Hui-Hui Su, Tao Shu, Xin Wu, Zheng-zhi Yu, Zhi-ling |
| Description | Country affiliation: Hong Kong Author Affiliation: Cheng BC ( Centre for Cancer and Inflammation Research, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong.); Ma XQ ( Centre for Cancer and Inflammation Research, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong.); Kwan HY ( Centre for Cancer and Inflammation Research, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong.); Tse KW ( Centre for Cancer and Inflammation Research, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong.); Cao HH ( Centre for Cancer and Inflammation Research, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong.); Su T ( Centre for Cancer and Inflammation Research, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong.); Shu X ( Centre for Cancer and Inflammation Research, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong.); Wu ZZ ( Shenzhen Institute of Integrative Medicine, Shenzhen Second People׳s Hospital, Shenzhen, China.); Yu ZL ( Centre for Cancer and Inflammation Research, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong. Electronic address: zlyu@hkbu.edu.hk.) |
| Abstract | ETHNOPHARMACOLOGICAL RELEVANCE: A herbal formula (RL) consisting of Rosae Multiflorae Fructus (Yingshi) and Lonicerae Japonicae Flos (Jinyinhua) has been traditionally used to treat inflammatory disorders. This study aims to investigate the anti-inflammatory mode and mechanism of action of the ethanol extract of RL so as to provide a pharmacological basis for the use of RL in treating inflammatory diseases. MATERIALS AND METHOD: RL consisting of Yingshi and Jinyinhua (in 5:3 ratio) was extracted using absolute ethanol. We investigated its effects on nitric oxide (NO), interleukin-6 (IL-6), tumour necrosis factor (TNF)- , inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), mitogen-activated protein kinases (MAPKs) and nuclear factor κB (NFκB) in mouse RAW 264.7 macrophages activated with lipopolysaccharide (LPS). RESULTS: RL could decrease the secretion of NO, IL-6 and TNF- into the culture medium and the cellular protein levels of iNOS and COX-2, which were associated with the reduction of the phosphorylation/activation of JNK and p38, and the inhibition of the transcriptional activity of NF-κB. CONCLUSIONS: The present study demonstrated an inhibitory effect of RL on the inflammatory mediators regulated by the NF-κB and MAPK signalling pathways in LPS-stimulated RAW 264.7 macrophages, providing a pharmacological basis for RL in the control of inflammatory disorders. |
| File Format | HTM / HTML |
| ISSN | 03788741 |
| Issue Number | 3 |
| Volume Number | 153 |
| e-ISSN | 18727573 |
| Journal | Journal of Ethnopharmacology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2014-05-14 |
| Publisher Place | Ireland |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Ethnopharmacology Anti-inflammatory Agents Pharmacology Lonicera Plant Extracts Rosaceae Animals Cell Line Cell Survival Drug Effects Cyclooxygenase 2 Metabolism Flowers Fruit Inflammation Mediators Interleukin-6 Lipopolysaccharides Macrophages Mice Mitogen-activated Protein Kinases Nf-kappa B Nitric Oxide Nitric Oxide Synthase Type Ii Tumor Necrosis Factor-alpha Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Drug Discovery Pharmacology |
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