| Author |
Silva, Mallone Lopes Luz, Diandra Araújo Paixão, Thiago Portal da Silva, João Paulo Bastos Belém-Filho, Ivaldo Jesus Almeida Fernandes, Luanna Melo Pereira Gonçalves, Ana Cristina Baetas Fontes-Júnior, Enéas Andrade de Andrade, Marciene Ataíde Maia, Cristiane Socorro Ferraz |
| Description |
Country affiliation: Brazil Author Affiliation: Silva ML ( Faculdade de Farmácia, Instituto de Ciências da Saúde, Universidade Federal do Pará, 66075-900 Belém, Pará, Brazil.); Luz DA ( Faculdade de Farmácia, Instituto de Ciências da Saúde, Universidade Federal do Pará, 66075-900 Belém, Pará, Brazil.); Paixão TP ( Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Pará, 66075-900 Belém, Pará, Brazil.); Silva JP ( Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Pará, 66075-900 Belém, Pará, Brazil.); Belém-Filho IJ ( Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Pará, 66075-900 Belém, Pará, Brazil.); Fernandes LM ( Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Pará, 66075-900 Belém, Pará, Brazil.); Gonçalves AC ( Faculdade de Farmácia, Instituto de Ciências da Saúde, Universidade Federal do Pará, 66075-900 Belém, Pará, Brazil.); Fontes-Júnior EA ( Faculdade de Farmácia, Instituto de Ciências da Saúde, Universidade Federal do Pará, 66075-900 Belém, Pará, Brazil.); de Andrade MA ( Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Pará, 66075-900 Belém, Pará, Brazil.); Maia CS ( Faculdade de Farmácia, Instituto de Ciências da Saúde, Universidade Federal do Pará, 66075-900 Belém, Pará, Brazil) |
| Abstract |
ETHNOPHARMACOLOGICAL RELEVANCE: Petiveria alliacea L. (Phytolaccaceae) is a perennial shrub native to the Amazon region and other tropical areas such as Central America and the Caribbean. Popularly known as mucuracaá, P. alliacea is used in the folk medicine for a broad variety of therapeutic purpose and also in religious ceremonies by slaves as a sedative, which highlights its properties on the Central Nervous System (CNS). AIM OF THE STUDY: The present study evaluated the effects of the P. alliacea leaves hydroalcoholic extract (PaLHE) on the cognition, including learning and memory. MATERIAL AND METHODS: Three-month-old male and female Wistar rats (n=8-10/group) were administered with 900mg/kg of PaLHE. The behavioral assays included Step-down Inhibitory avoidance (IA) and Morris Water Maze (MWM) tests. RESULTS: Consistent with our previous reports, P. alliacea improved long-term memory. It also exerted previously unreported effects on short-term and spatial memory improvement, and increased learning in the tasks. CONCLUSIONS: The P. alliacea extract elicited mnemonic effects and improved the learning process in both IA and MWM tests. Our results highlight the importance of further studies in order to identify the active substances of the PaLHE and investigate the pharmacological mechanisms that underlies the reported effects. |
