| Content Provider |
World Health Organization (WHO)-Global Index Medicus |
| Author |
da Silva, Rafaela Oliveira Andrade, Valléria Matos Bullé Rêgo, Ester Seixas Azevedo Dória, Grace Anne Santos Lima, Bruno Dos da Silva, Francilene Amaral de Souza Araújo, Adriano Antunes de Albuquerque Júnior, Ricardo Luiz Cavalcanti Cordeiro Cardoso, Juliana Zanardo Gomes, Margarete |
| Spatial Coverage |
Brazil |
| Description |
Country affiliation: Brazil Author Affiliation: da Silva RO ( Tiradentes University, 300 Murilo Dantas Ave, Farolândia 49032-490 Aracaju, SE, Brazil.); Andrade VM ( Tiradentes University, 300 Murilo Dantas Ave, Farolândia 49032-490 Aracaju, SE, Brazil.); Bullé Rêgo ES ( Tiradentes University, 300 Murilo Dantas Ave, Farolândia 49032-490 Aracaju, SE, Brazil); Azevedo Dória GA ( Tiradentes University, 300 Murilo Dantas Ave, Farolândia 49032-490 Aracaju, SE, Brazil); Santos Lima BD ( Department of Pharmacy, Federal University of Sergipe, Marechal Rondon Ave, Cidade Universitária, CEP 49100-000 São Cristóvão, SE, Brazil.); da Silva FA ( Department of Pharmacy, Federal University of Sergipe, Marechal Rondon Ave, Cidade Universitária, CEP 49100-000 São Cristóvão, SE, Brazil.); de Souza Araújo AA ( Department of Pharmacy, Federal University of Sergipe, Marechal Rondon Ave, Cidade Universitária, CEP 49100-000 São Cristóvão, SE, Brazil.); de Albuquerque Júnior RL ( Tiradentes University, 300 Murilo Dantas Ave, Farolândia 49032-490 Aracaju, SE, Brazil); Cordeiro Cardoso J ( Tiradentes University, 300 Murilo Dantas Ave, Farolândia 49032-490 Aracaju, SE, Brazil); Zanardo Gomes M ( Tiradentes University, 300 Murilo Dantas Ave, Farolândia 49032-490 Aracaju, SE, Brazil) |
| Abstract |
ETHNOPHARMACOLOGICAL RELEVANCE: Propolis is a bee product widely used in folk medicine due to its numerous pharmacological properties. However, samples from different regions can differ in chemical composition, effectiveness, and side effects. Despite the widespread use of Brazilian red propolis, which is an isoflavone-rich variety, its toxicity has not been carefully studied. AIMS OF THE STUDY: To assess the acute and sub-acute toxicity of the hydroethanolic extract of red propolis (HERP) administered orally to rats. MATERIALS AND METHODS: HERP for the acute (300mg/kg) and sub-acute (10, 100 and 200mg/kg) toxicity studies was administered orally to rats according to OECD Guidelines 420 and 407, respectively. Clinical signs were identified, and hematological and biochemical analyses were performed. Water and food uptake as well as body and organ weights of animals were recorded. RESULTS AND CONCLUSIONS: The acute study revealed no lethal effects at 300mg/kg of HERP, but toxic signs were observed, as HERP had an LD50 of more than 300mg/kg, indicating a warning. The most toxic signals in sub-acute studies were observed in males at a dose of 200mg/kg HERP. These results suggest estrogen-like activity, possibly from the isoflavones in HERP. |
| File Format |
HTM / HTML |
| ISSN |
03788741 |
| Volume Number |
170 |
| e-ISSN |
18727573 |
| Journal |
Journal of Ethnopharmacology |
| Language |
English |
| Publisher |
Elsevier |
| Publisher Date |
2015-07-21 |
| Publisher Place |
Ireland |
| Access Restriction |
One Nation One Subscription (ONOS) |
| Subject Keyword |
Discipline Ethnopharmacology Bees Isoflavones Toxicity Propolis Administration, Oral Animals Brazil Dose-response Relationship, Drug Female Isolation & Purification Lethal Dose 50 Male Medicine, Traditional Organ Size Drug Effects Administration & Dosage Rats Rats, Wistar Sex Factors Toxicity Tests, Acute Toxicity Tests, Subacute Journal Article Research Support, Non-u.s. Gov't |
| Content Type |
Text |
| Resource Type |
Article |
| Subject |
Drug Discovery Pharmacology |
