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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Sagradas, Joana Costa, Gustavo Figueirinha, Artur Castel-Branco, Maria Margarida Silvério Cabrita, António Manuel Figueiredo, Isabel Vitória Batista, Maria Teresa |
| Description | Country affiliation: Portugal Author Affiliation: Sagradas J ( Group of Pharmacology and Pharmaceutical Care, Faculty of Pharmacy, University of Coimbra, Portugal.); Costa G ( Center of Neurosciences and Cell Biology, University of Coimbra, Portugal.); Figueirinha A ( Department of Environment, Polytechnic Institute of Viseu, Portugal.); Castel-Branco MM ( Group of Pharmacology and Pharmaceutical Care, Faculty of Pharmacy, University of Coimbra, Portugal); Silvério Cabrita AM ( Experimental Pathology Institute, Faculty of Medicine, University of Coimbra, Portugal.); Figueiredo IV ( Group of Pharmacology and Pharmaceutical Care, Faculty of Pharmacy, University of Coimbra, Portugal); Batista MT ( Center of Neurosciences and Cell Biology, University of Coimbra, Portugal. Electronic address: mtpmb@ff.uc.pt.) |
| Abstract | ETHNOPHARMACOLOGICAL RELEVANCE: Treatment of gastric ulcers with medicinal plants is quite common in traditional medicine worldwide. Cymbopogon citratus (DC) Stapf. leaves infusion has been used in folk medicine of many tropical and subtropical regions to treat gastric disturbances. The aim of this study was to assess the potential gastroprotective activity of an essential oil-free infusion from C. citratus leaves in acute gastric lesions induced by ethanol in rat. MATERIALS AND METHODS: The study was performed on adult male Wistar rats (234.0±22.7g) fasted for 24h but with free access to water. The extract was given orally before (prevention) or after (treatment) intragastric administration of absolute ethanol. Effects of dose (28 or 56mg/kg of body weight) and time of contact of the extract with gastric mucosa (1 or 2h) were also assessed. Animals were sacrificed, being the stomachs removed and the lesions were assessed by macroscopic observation and histopathology. RESULTS: C. citratus extract, given orally before or after ethanol, significantly (P<0.01) reduced gastric mucosal injury compared with control group (vehicle+ethanol). The effect does not appear to be dose-dependent. Results also suggested that the extract is more effective when the time of contact with gastric mucosa increases. CONCLUSIONS: The results of this assay confirm the gastroprotective activity of C. citratus extract on experimental gastric lesions induced by ethanol, contributing for the pharmacological validation of its traditional use. |
| File Format | HTM / HTML |
| ISSN | 03788741 |
| Volume Number | 173 |
| e-ISSN | 18727573 |
| Journal | Journal of Ethnopharmacology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2015-09-15 |
| Publisher Place | Ireland |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Ethnopharmacology Anti-ulcer Agents Therapeutic Use Cymbopogon Plant Extracts Stomach Ulcer Drug Therapy Animals Ethanol Gastric Mucosa Drug Effects Pathology Male Phytotherapy Rats, Wistar Chemically Induced Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Drug Discovery Pharmacology |
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