NDLI: Highly active antiretroviral treatment does not increase sexual risk behaviour among French HIV infected injecting drug users.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Bouhnik, A-D Moatti, J. P. Vlahov, D. Gallais, H. Dellamonica, P. Obadia, Y.
Spatial Coverage	France
Description	Country affiliation: France Author Affiliation: Bouhnik AD ( Regional Centre for Disease Control of South-Eastern France (ORS-PACA), Marseilles, France.)
Abstract	STUDY OBJECTIVE: This study examined the impact of highly active antiretroviral therapies (HAART) on sexual risk behaviours of HIV infected injecting drug users (IDUs) included in the French MANIF 2000 cohort study. DESIGN: Longitudinal analysis including baseline and last follow up characteristics using generalised estimating equations (GEE). SETTING: Hospital departments for specialist AIDS care in south eastern France and inner suburbs of Paris. PATIENTS: All patients antiretrovial treatment naive, who reported being sexually active at enrollment, and who had at least one follow up visit in the cohort between October 1996 and May 1998 (n=188). MAIN RESULTS: Of the 188 HIV infected IDUs who were antiretroviral treatment naive at enrollment, 34 were prescribed HAART during follow up. Proportion of patients who reported at least one episode of unprotected sexual intercourse in the previous six months only significantly decreased in the HAART treated group (from 47.1% to 23.5%, p=0.008, compared with 43.5% to 35.7% in the rest of the sample, p=0.10). GEE multivariate model confirmed that prescription of HAART was associated with reduced sexual risk. CONCLUSIONS: The concern that HAART might result in clinical improvement leading to resumption of high risk activities that could inadvertently result in HIV transmission was not supported by these data. Reasons for further reductions in HIV risk with taking HAART remain to be clarified.
File Format	HTM / HTML
ISSN	0143005X
e-ISSN	14702738
Journal	Journal of Epidemiology & Community Health
Issue Number	5
Volume Number	56
Language	English
Publisher	BMJ Group
Publisher Date	2002-05-01
Publisher Place	Great Britain (UK)
Access Restriction	Open
Subject Keyword	Discipline Health__semicolon__epidemiology Antiretroviral Therapy, Highly Active Hiv Infections Drug Therapy Transmission Substance Abuse, Intravenous Psychology Prospective Studies Risk-taking Sexual Behavior Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Public Health, Environmental and Occupational Health Epidemiology

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