NDLI: Acute norepinephrine reuptake inhibition decreases performance in normal and high ambient temperature.

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Acute norepinephrine reuptake inhibition decreases performance in normal and high ambient temperature.

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Good bye 'lactic acid'; hello lactate and acid.

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Acute norepinephrine reuptake inhibition decreases performance in normal and high ambient temperature.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Roelands, Bart Goekint, Maaike Heyman, Elsa Piacentini, Maria Francesca Watson, Philip Hasegawa, Hiroshi Buyse, Luk Pauwels, Frank De Schutter, Guy Meeusen, Romain
Description	Country affiliation: Belgium Author Affiliation: Roelands B ( Department of Human Physiology and Sports Medicine, Faculty of Physical Education and Physiotherapy, Vrije Universiteit Brussel, Brussels, Belgium.)
Abstract	Combined inhibition of dopamine (DA)/norepinephrine (NE) reuptake improves exercise performance and increases core temperature in the heat. A recent study demonstrated that this effect may primarily be related to increased DA activity. NE reuptake inhibition (NERI), however, has received little attention in humans, certainly in the heat, where central fatigue appears to be a main factor influencing performance. Therefore the present study examines the effect of NERI (reboxetine) on exercise capacity, thermoregulation, and hormonal response in normal and high temperature. Nine healthy well-trained male cyclists participated in this study. Subjects ingested either placebo (Pla; 2 x 8 mg) or reboxetine (Rebox; 2 x 8 mg). Subjects exercised in temperate (18 degrees C) or warm (30 degrees C) conditions and cycled for 60 min at 55% W(max) immediately followed by a time trial (TT; Pla18/Rebox18; Pla30/Rebox30) to measure exercise performance. Acute NERI decreased power output and consequently exercise performance in temperate (P = 0.018) and warm (P = 0.007) conditions. Resting heart rate was significantly elevated by NERI (18 degrees C: P = 0.02; 30 degrees C: P = 0.018). In Rebox18, heart rate was significantly higher than in the Pla18, while in the heat no effect of the drug treatment was reported during exercise. In Rebox30, all hormone concentrations increased during exercise, except for growth hormone (GH), which was significantly lower during exercise. In Rebox18, prolactin (PRL) concentrations were significantly elevated; GH was significantly higher at rest, but significantly lower during exercise. In conclusion, manipulation of the NE system decreases performance and modifies hormone concentrations, thereby indicating a central NE effect of the drug. These findings confirm results from previous studies that predominantly increased DA activity is important in improving performance.
File Format	HTM / HTML
ISSN	87507587
e-ISSN	15221601
Journal	Journal of Applied Physiology
Issue Number	1
Volume Number	105
Language	English
Publisher	American Physiological Society
Publisher Date	2008-07-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Physiology Adrenergic Uptake Inhibitors Pharmacology Physiology Hot Temperature Norepinephrine Adrenal Cortex Hormones Blood Bicycling Blood Pressure Drug Effects Body Temperature Regulation Heart Rate Morpholines Muscle Fatigue Pituitary Hormones Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Physiology Physiology (medical) Sports Science

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