NDLI: Sensitizing effects of chronic exposure and acute inhalation of ovalbumin aerosol on pulmonary C fibers in rats.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Zhang, Guangfan Lin, Ruei-Lung Wiggers, Michelle E. Lee, Lu-Yuan
Description	Country affiliation: United States Author Affiliation: Zhang G ( Department of Physiology, University of Kentucky Medical Center, 800 Rose St., Lexington, KY 40536-0298, USA.)
Abstract	The effect of ovalbumin (Ova) sensitization on pulmonary C-fiber sensitivity was investigated. Brown-Norway rats were sensitized by intraperitoneal injection of Ova followed by aerosolized Ova three times per week for 3 wk. Control rats received the vehicle. At the end of the third week, single-unit fiber activities (FA) of pulmonary C fibers were recorded in anesthetized, artificially ventilated rats. Our results showed the following: 1) Ova sensitization induced airway inflammation (infiltration of eosinophils and neutrophils) and airway hyperresponsiveness in rats; 2) baseline FA in sensitized rats was significantly higher than that in control ones; 3) similarly, the pulmonary C-fiber response to right atrial injection of capsaicin was markedly higher in sensitized rats, which were significantly amplified after the acute Ova inhalation challenge; and 4) similar patterns, but smaller magnitudes of the differences in C-fiber responses to adenosine and lung inflation, were also found between sensitized and control rats. In conclusion, Ova sensitization elevated the baseline FA and excitability of pulmonary C fibers, and the hypersensitivity was further potentiated after the acute Ova inhalation challenge in sensitized rats. Chronic allergic inflammatory reactions in the airway probably contributed to the sensitizing effect on these lung afferents.
File Format	HTM / HTML
ISSN	87507587
e-ISSN	15221601
DOI	10.1152/japplphysiol.01367.2007
Journal	Journal of Applied Physiology
Issue Number	1
Volume Number	105
Language	English
Publisher	American Physiological Society
Publisher Date	2008-07-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Physiology Hypersensitivity Immunology Lung Nerve Fibers, Unmyelinated Physiology Ovalbumin Administration, Inhalation Aerosols Allergens Administration & Dosage Animals Blood Pressure Drug Effects Bronchial Hyperreactivity Physiopathology Bronchoconstrictor Agents Pharmacology Dose-response Relationship, Drug Heart Rate Inflammation Pathology Methacholine Chloride Neurons, Afferent Rats, Inbred Bn Research Support, N.i.h., Extramural
Content Type	Text
Resource Type	Article
Subject	Physiology Physiology (medical) Sports Science

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