NDLI: Nonselective NOS inhibition blunts the sweat response to exercise in a warm environment.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Welch, Garrett Foote, Kristopher M. Hansen, Crystelle Mack, Gary W.
Description	Country affiliation: United States Author Affiliation: Welch G ( Department of Exercise Sciences, Brigham Young University, Provo, Utah 84602, USA.)
Abstract	The role of nitric oxide synthase (NOS) inhibition in modulating human thermoregulatory control of sweating and cutaneous dilation was examined in 10 subjects (5 men and 5 women). Three intradermal microdialysis probes were placed in nonglabrous skin of the dorsum of the forearm. The control site was perfused with 0.9% saline, while the two remaining sites were perfused with a nonselective NOS inhibitor: 10 mM N(G)-nitro-L-arginine (L-NAME) or 10 mM N(G)-monomethyl-L-arginine (L-NMMA). Local sweat rate (SR) and skin blood flow (laser-Doppler velocimetry) were monitored directly over the path of the intradermal microdialysis probe while arterial blood pressure was measured in the opposite arm noninvasively. Thermoregulatory responses were induced by cycle ergometer exercise (60% peak oxygen consumption) in a warm environment (30 degrees C). Esophageal temperature increased 1.5 +/- 0.2 degrees C during the 30 min of exercise. The cutaneous dilator response between 5 and 30 min of exercise in the heat was attenuated by both 10 mM L-NAME and 10 mM L-NMMA (P < 0.05). However, 10 mM L-NAME was more effective in blunting the rise in cutaneous vascular conductance during exercise than L-NMMA (P < 0.05). NOS inhibition also reduced the rise in local SR between 10 and 30 min of exercise (P < 0.05). In this case, 10 mM L-NMMA was more effective in limiting the increase in local SR than 10 mM L-NAME (P < 0.05). We conclude that local production of nitric oxide in the skin or around the sweat gland augments local SR and cutaneous dilation during exercise in the heat.
File Format	HTM / HTML
ISSN	87507587
e-ISSN	15221601
DOI	10.1152/japplphysiol.90809.2008
Journal	Journal of Applied Physiology
Issue Number	3
Volume Number	106
Language	English
Publisher	American Physiological Society
Publisher Date	2009-03-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Physiology Enzyme Inhibitors Pharmacology Ng-nitroarginine Methyl Ester Nitric Oxide Synthase Antagonists & Inhibitors Sweating Drug Effects Omega-n-methylarginine Blood Flow Velocity Blood Pressure Body Temperature Physiology Regional Blood Flow Skin Blood Supply Enzymology Sweat Glands Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Physiology Physiology (medical) Sports Science

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Cyclooxygenase inhibition does not alter methacholine-induced sweating.

Characterization of nitric oxide synthase activity in sheep urinary tract: functional implications.

Protective effects of inhibitors of nitric oxide synthase in immune complex-induced vasculitis.

Characterization of three inhibitors of endothelial nitric oxide synthase in vitro and in vivo.

Time-dependent enhancement or inhibition of endotoxin-induced vascular injury in rat intestine by nitric oxide synthase inhibitors.

Resistance to renal damage by chronic nitric oxide synthase inhibition in the Wistar-Furth rat.

Role of endothelin-1 in the hyper-responsiveness to nitrovasodilators following acute NOS inhibition.

Local NOS inhibition impairs vascular and metabolic actions of insulin in rat hindleg muscle in vivo.

Inhibitors of nitric oxide synthase selectively reduce flow in tumor-associated neovasculature.

Nonselective NOS inhibition blunts the sweat response to exercise in a warm environment.

Similar Documents

Cyclooxygenase inhibition does not alter methacholine-induced sweating.

Characterization of nitric oxide synthase activity in sheep urinary tract: functional implications.

Protective effects of inhibitors of nitric oxide synthase in immune complex-induced vasculitis.

Characterization of three inhibitors of endothelial nitric oxide synthase in vitro and in vivo.

Time-dependent enhancement or inhibition of endotoxin-induced vascular injury in rat intestine by nitric oxide synthase inhibitors.

Resistance to renal damage by chronic nitric oxide synthase inhibition in the Wistar-Furth rat.

Role of endothelin-1 in the hyper-responsiveness to nitrovasodilators following acute NOS inhibition.

Local NOS inhibition impairs vascular and metabolic actions of insulin in rat hindleg muscle in vivo.

Inhibitors of nitric oxide synthase selectively reduce flow in tumor-associated neovasculature.

Nonselective NOS inhibition blunts the sweat response to exercise in a warm environment.