NDLI: Continued artificial selection for running endurance in rats is associated with improved lung function.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Kirkton, Scott D. Howlett, Richard A. Gonzalez, Norberto C. Giuliano, Patrick G. Britton, Steven L. Koch, Lauren G. Wagner, Harrieth E. Wagner, Peter D.
Description	Country affiliation: United States Author Affiliation: Kirkton SD ( Department of Medicine, University of California, La Jolla, CA 92093-0623, USA.)
Abstract	Previous studies found that selection for endurance running in untrained rats produced distinct high (HCR) and low (LCR) capacity runners. Furthermore, despite weighing 14% less, 7th generation HCR rats achieved the same absolute maximal oxygen consumption (Vo(2max)) as LCR due to muscle adaptations that improved oxygen extraction and use. However, there were no differences in cardiopulmonary function after seven generations of selection. If selection for increased endurance capacity continued, we hypothesized that due to the serial nature of oxygen delivery enhanced cardiopulmonary function would be required. In the present study, generation 15 rats selected for high and low endurance running capacity showed differences in pulmonary function. HCR, now 25% lighter than LCR, reached a 12% higher absolute Vo(2max) than LCR, P < 0.05 (49% higher Vo(2max)/kg). Despite the 25% difference in body size, both lung volume (at 20 cmH(2)O airway pressure) and exercise diffusing capacity were similar in HCR and LCR. Lung volume of LCR lay on published mammalian allometrical relationships while that of HCR lay above that line. Alveolar ventilation at Vo(2max) was 30% higher, P < 0.05 (78% higher, per kg), arterial Pco(2) was 4.5 mmHg (17%) lower, P < 0.05, while total pulmonary vascular resistance was (insignificantly) 5% lower (30% lower, per kg) in HCR. The smaller mass of HCR animals was due mostly to a smaller body frame rather than to a lower fat mass. These findings show that by generation 15, lung size in smaller HCR rats is not reduced in concert with their smaller body size, but has remained similar to that of LCR, supporting the hypothesis that continued selection for increased endurance capacity requires relatively larger lungs, supporting greater ventilation, gas exchange, and pulmonary vascular conductance.
File Format	HTM / HTML
ISSN	87507587
e-ISSN	15221601
DOI	10.1152/japplphysiol.90419.2008
Journal	Journal of Applied Physiology
Issue Number	6
Volume Number	106
Language	English
Publisher	American Physiological Society
Publisher Date	2009-06-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Physiology Exercise Tolerance Genetics Lung Physiology Oxygen Consumption Pulmonary Gas Exchange Selection, Genetic Animals Breeding Anatomy & Histology Models, Genetic Muscle, Skeletal Metabolism Organ Size Oxygen Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Physiology Physiology (medical) Sports Science

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