NDLI: Pulse arrival time is not an adequate surrogate for pulse transit time as a marker of blood pressure.

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Pulse arrival time is not an adequate surrogate for pulse transit time as a marker of blood pressure.

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Pulse arrival time is not an adequate surrogate for pulse transit time as a marker of blood pressure.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Zhang, Guanqun Gao, Mingwu Xu, Da Olivier, N. Bari Mukkamala, Ramakrishna
Description	Country affiliation: United States Author Affiliation: Zhang G ( Dept. of Electrical and Computer Engineering, Michigan State Univ., East Lansing, MI 48824-1226, USA.)
Abstract	Pulse transit time (PTT) is a proven, simple to measure, marker of blood pressure (BP) that could potentially permit continuous, noninvasive, and cuff-less BP monitoring (after an initial calibration). However, pulse arrival time (PAT), which is equal to the sum of PTT and the pre-ejection period, is gaining popularity for BP tracking, because it is even simpler to measure. The aim of this study was to evaluate the hypothesis that PAT is an adequate surrogate for PTT as a marker of BP. PAT and PTT were estimated through the aorta using high-fidelity invasive arterial waveforms obtained from six dogs during wide BP changes induced by multiple interventions. These time delays and their reciprocals were evaluated in terms of their ability to predict diastolic, mean, and systolic BP (DBP, MBP, and SBP) per animal. The root mean squared error (RMSE) between the BP parameter predicted via the time delay and the measured BP parameter was specifically used as the evaluation metric. Taking the reciprocals of the time delays tended to reduce the RMSE values. The DBP, MBP, and SBP RMSE values for 1/PAT were 9.8 ± 5.2, 10.4 ± 5.6, and 11.9 ± 6.1 mmHg, whereas the corresponding values for 1/PTT were 5.3 ± 1.2, 4.8 ± 1.0, and 7.5 ± 2.2 mmHg (P < 0.05). Thus tracking BP via PAT was not only markedly worse than via PTT but also unable to meet the FDA BP error limits. In contrast to previous studies, our results quantitatively indicate that PAT is not an adequate surrogate for PTT in terms of detecting challenging BP changes.
File Format	HTM / HTML
ISSN	87507587
e-ISSN	15221601
Journal	Journal of Applied Physiology
Issue Number	6
Volume Number	111
Language	English
Publisher	American Physiological Society
Publisher Date	2011-12-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Physiology Blood Pressure Determination Blood Pressure Physiology Pulse Animals Cardiovascular Physiological Phenomena Diastole Heart Rate Monitoring, Physiologic Systole Time Factors Comparative Study Evaluation Studies Research Support, Non-u.s. Gov't Research Support, U.s. Gov't, Non-p.h.s.
Content Type	Text
Resource Type	Article
Subject	Physiology Physiology (medical) Sports Science

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