NDLI: Defining a stimuli-response relationship in compensatory lung growth following major resection.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Ravikumar, Priya Yilmaz, Cuneyt Dane, D. Merrill Bellotto, Dennis J. Estrera, Aaron S. Hsia, Connie C. W.
Description	Author Affiliation: Ravikumar P ( Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas.)
Abstract	Major lung resection is a robust model that mimics the consequences of loss-of-functioning lung units. We previously observed in adult canines, following 42% and 58% lung resection, a critical threshold of stimuli intensity for the initiation of compensatory lung growth. To define the range and limits of this stimuli-response relationship, we performed morphometric analysis on the remaining lobes of adult dogs, 2-3 years after surgical removal of â¼ 70% of lung units in the presence or absence of mediastinal shift. Results were expressed as ratios to that in corresponding control lobes. Lobar expansion and extravascular tissue growth (â¼ 3.8- and â¼ 2.0-fold of normal, respectively) were heterogeneous; the lobes remaining next to the diaphragm exhibited a greater response. Tissue growth and capillary formation, indexed by double-capillary profiles, increased, regardless of mediastinal shift. Septal collagen fibers increased up to 2.7-fold, suggesting a greater need for structural support. Compared with previous cohorts following less-extensive resection, tissue volume and gas-exchange surface areas increased significantly only in the infracardiac lobe following 42% resection, exceeded two- to threefold in all lobes following 58% resection, and then exhibited diminished gains following â¼ 70% resection. In contrast, alveolar-capillary formation increased with incremental resection without reaching an upper limit. Overall structural regrowth was most vigorous and uniform following 58% resection. The diminishment of gains in tissue growth, following â¼ 70% resection, could reflect excessive or maldistributed mechanical stress that threatens septal integrity. Results also suggest additional independent stimuli of alveolar-capillary formation, possibly related to the postresection augmentation of regional perfusion.
File Format	HTM / HTML
ISSN	87507587
e-ISSN	15221601
DOI	10.1152/japplphysiol.01291.2013
Journal	Journal of Applied Physiology
Issue Number	7
Volume Number	116
Language	English
Publisher	American Physiological Society
Publisher Date	2014-04-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Physiology Lung Surgery Pneumonectomy Regeneration Animals Capillaries Physiopathology Cell Proliferation Collagen Metabolism Blood Supply Pathology Mechanotransduction, Cellular Neovascularization, Physiologic Pulmonary Gas Exchange Stress, Mechanical Time Factors Comparative Study Research Support, N.i.h., Extramural
Content Type	Text
Resource Type	Article
Subject	Physiology Physiology (medical) Sports Science

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