NDLI: Mold allergen sensitization in adult asthma according to integrin ß3 polymorphisms and Toll-like receptor 2/+596 genotype.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Smit, Lidwien A. M. Bouzigon, Emmanuelle Bousquet, Jean Le Moual, Nicole Nadif, Rachel Pin, Isabelle Lathrop, Mark Demenais, Florence Kauffmann, Francine Siroux, Valérie
Description	Country affiliation: Netherlands Author Affiliation: Smit LA ( Institute for Risk Assessment Sciences, Division of Environmental Epidemiology, Utrecht University, Utrecht, The Netherlands. L.A.Smit@uu.nl)
Abstract	BACKGROUND: Integrin ß3 (ITGB3) and Toll-like receptor 2 (TLR2) are candidate genes for asthma and sensitization to mold allergens. Integrin ß3 forms a complex with TLR2, and this biological interaction is required for the response of monocytes to TLR2 agonists such as fungal glucan. OBJECTIVE: To study whether genetic interaction between single nucleotide polymorphisms (SNPs) in genes encoding the TLR2-ITGB3 complex enhances susceptibility to mold sensitization. METHODS: Association analysis was conducted in 1243 adults (524 with asthma) who participated in the follow-up of the Epidemiological Study on the Genetics and Environment of Asthma. Allergic sensitization to mold allergens was determined by skin prick testing. Association of mold sensitization with 14 ITGB3 SNPs was tested under an additive genetic model. Interaction between ITGB3 SNPs and TLR2/+596, which was previously shown to be associated with asthma, was studied. RESULTS: A positive skin prick test to mold was found in 115 subjects with asthma (22.0%) and in 61 subjects without asthma (8.5%). The ITGB3 rs2056131 A allele was associated with mold sensitization in subjects with asthma with an odds ratio (95% CI) of 0.60 (0.43-0.83; P = .001). Ten other ITGB3 SNPs were significantly associated with mold sensitization in TLR2/+596TT subjects with asthma (P = .03-.002), whereas much weaker associations were found in carriers of the TLR2/+596 C allele (P = .60-.04). Interaction between TLR2/+596 and these ITGB3 SNPs was statistically significant (P interaction = .05-.001). CONCLUSION: TLR2/+596 genotype may influence the association between ITGB3 SNPs and mold sensitization in adults with asthma.
File Format	HTM / HTML
ISSN	00916749
e-ISSN	10976825
Journal	Journal of Allergy and Clinical Immunology
Issue Number	1
Volume Number	128
Language	English
Publisher	Elsevier
Publisher Date	2011-07-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Immunology Asthma Genetics Fungi Immunology Genetic Predisposition To Disease Hypersensitivity Integrin Beta3 Polymorphism, Single Nucleotide Toll-like Receptor 2 Allergens Genotype Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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