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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Schatz, Michael Zeiger, Robert S. Yang, Su-Jau Chen, Wansu Kosinski, Mark |
| Description | Country affiliation: United States Author Affiliation: Schatz M ( Department of Allergy, Kaiser Permanente Medical Center, San Diego, CA 92111, USA. michael.x.schatz@kp.org) |
| Abstract | BACKGROUND: The Asthma Impact Survey (AIS-6) is a brief disease-specific quality-of-life instrument with limited published validation data. OBJECTIVE: To obtain additional validation data and psychometric properties of the AIS-6. METHODS: In November, 2007, patients with persistent asthma were mailed a survey that included the AIS-6, the mini-Asthma Quality of Life Questionnaire (mAQLQ), and the Asthma Control Test (ACT). Follow-up surveys were sent in April, July, and October 2008. Year 2008 exacerbations and short-acting ß-agonist (SABA) dispensings were captured from administrative data. RESULTS: A total of 2680 patients had complete baseline survey data. Criterion validity was demonstrated by the strong correlations of the AIS-6 with the mAQLQ (r = -0.84 to -0.86); construct validity by significant relationships (P < .0001) of the AIS-6 with mAQLQ domain scores, ACT score, and history of exacerbations; and predictive validity by significant relationships (P < .0001) between AIS-6 scores at the end of 2007 and year 2008 exacerbations and high SABA dispensings. Responsiveness was demonstrated by significant (P < .0001) correlations (r = -0.39 to -0.58) between changes in AIS-6 scores and changes in mAQLQ and ACT scores over time. A preliminary minimally important difference (MID) in AIS-6 was estimated to be 4 by using the mAQLQ MID as an anchor. Excellent internal consistency ( = 0.94) and test-retest reliability (intraclass correlation coefficient = 0.86-0.91) were also demonstrated. CONCLUSION: The AIS-6 demonstrated good psychometric properties in a large independent sample and could be used to assess asthma-specific quality of life in clinical practice and clinical research. |
| File Format | HTM / HTML |
| ISSN | 00916749 |
| e-ISSN | 10976825 |
| Journal | Journal of Allergy and Clinical Immunology |
| Issue Number | 1 |
| Volume Number | 128 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2011-07-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Discipline Immunology Asthma Psychology Health Surveys Psychometrics Quality Of Life Severity Of Illness Index Complications Reproducibility Of Results Validation Studies |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology and Allergy Immunology |
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