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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Sokol, Harry Georgin-Lavialle, Sophie Canioni, Danielle Barete, Stéphane Damaj, Gandhi Soucie, Erinn Bruneau, Julie Chandesris, Marie-Olivia Suarez, Felipe Launay, Jean-Marie Aouba, Achille Grandpeix-Guyodo, Catherine Lanternier, Fanny Grosbois, Bernard de Gennes, Christian Cathébras, Pascal Fain, Olivier Hoyeau-Idrissi, Nadia Dubreuil, Patrice Lortholary, Olivier Beaugerie, Laurent Ranque, Brigitte Hermine, Olivier |
| Description | Country affiliation: France Author Affiliation: Sokol H ( Service de Gastroentérologie et Nutrition, Hôpital Saint-Antoine, AP-HP, Université Pierre et Marie Curie-Paris 6, Paris, France) |
| Abstract | BACKGROUND: Mastocytosis is a heterogeneous disease characterized by mast cell accumulation in 1 or more organs. Gastrointestinal manifestations of systemic mastocytosis have been previously studied in small cohorts of patients, and no specific histologic description is available. OBJECTIVE: We sought to assess the clinical and pathologic features of gastrointestinal manifestations in patients with mastocytosis. METHODS: Medical history and gastrointestinal symptoms of patients with mastocytosis (n = 83) were compared with those of matched healthy subjects (n = 83) by means of patient questionnaire. Data were analyzed for epidemiologic, clinical, biological, and genetic factors associated with gastrointestinal symptoms for patients with mastocytosis. A comparative analysis of gastrointestinal histology from patients with mastocytosis (n = 23), control subjects with inflammatory bowel disease (n = 17), and healthy subjects (n = 19) was performed. RESULTS: The following gastrointestinal symptoms occurred more frequently and were more severe in patients with mastocytosis than in healthy subjects: bloating (33% vs 7.2%, P < .0001), abdominal pain (27.3% vs 4.8%, P < .0001), nausea (23% vs 8.4%, P = .02), and diarrhea (33.85% vs 1.2%, P < .0001). Patients with mastocytosis had a significantly higher incidence of personal history of duodenal ulcer (P = .02). Wild-type (WT) c-Kit was associated with diarrhea (P = .03). Specific histologic lesions were present in patients with mastocytosis but were not correlated with clinical symptoms. CONCLUSION: Gastrointestinal manifestations in patients with mastocytosis are highly prevalent and often severe. Clinical symptoms do not correspond to histologic findings, are nonspecific, and can simulate irritable bowel syndrome. |
| File Format | HTM / HTML |
| ISSN | 00916749 |
| e-ISSN | 10976825 |
| Journal | Journal of Allergy and Clinical Immunology |
| Issue Number | 4 |
| Volume Number | 132 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2013-10-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Discipline Immunology Gastrointestinal Diseases Pathology Physiopathology Mastocytosis, Systemic Biopsy Case-control Studies Diarrhea Metabolism Immunology Gastrointestinal Tract Proto-oncogene Proteins C-kit Severity Of Illness Index Questionnaires Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology and Allergy Immunology |
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