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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Bijak, Michal Kolodziejczyk-Czepas, Joanna Ponczek, Michal Blazej Saluk, Joanna Nowak, Pawel |
| Description | Country affiliation: Poland Author Affiliation: Bijak M ( Department of General Biochemistry, University of Lodz, Pomorska 141/143, 90-236 Lodz, Poland. mbijak@biol.uni.lodz.pl) |
| Abstract | Oxidative stress, vascular inflammation, endothelial dysfunction plays a crucial role in the pathogenesis of cardiovascular diseases. The aim of our in vitro study was to examine the antioxidative properties of grape seed extract, and its potential protective effect on the haemostatic function of human fibrinogen under oxidative stress conditions, induced by peroxynitrite (100 µM). The preincubation of plasma with the tested extract (0.5-50 µg/ml or 0.5-300 µg/ml) reduced the formation of 3-nitrotyrosine and diminished oxidation of thiol groups in plasma proteins. The low concentrations (0.5-50 µg/ml) of grape seed extract also decreased the level of carbonyl groups, however at higher concentrations (100-300 µg/ml) this effect was not observed. Furthermore, grape seed extract counteracted the inhibitory effect of peroxynitrite on human plasma clotting. The results obtained in this study indicate that components of the grape seed extract posses antioxidative properties and may be promising substances for the creation of new dietary supplements. |
| File Format | HTM / HTML |
| ISSN | 01418130 |
| Issue Number | 3 |
| Volume Number | 51 |
| e-ISSN | 18790003 |
| Journal | International Journal of Biological Macromolecules |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2012-10-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Biochemistry Antioxidants Pharmacology Blood Proteins Metabolism Grape Seed Extract Humans Oxidation-reduction Drug Effects Oxidative Stress Tyrosine Analogs & Derivatives Blood Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Structural Biology Molecular Biology Biochemistry |
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