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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Chaari, Ali Hoarau-Véchot, Jessica Ladjimi, Moncef |
| Description | Country affiliation: Qatar Author Affiliation: Chaari A ( Department of Biochemistry, Weill Cornell Medical College in Qatar, Qatar Foundation, Education City, Doha, Qatar. alc2033@qatar-med.cornell.edu) |
| Abstract | Parkinson's disease (PD) is a neurodegenerative disorder characterized by the accumulation of a protein called -synuclein ( -syn) into inclusions known as lewy bodies (LB) within neurons. This accumulation is also due to insufficient formation and activity of dopamine produced in certain neurons within the substantia nigra. Lewy bodies are the pathological hallmark of the idiopathic disorder and the cascade that allows -synuclein to misfold, aggregate and form these inclusions has been the subject of intensive research. Targeting these early steps of oligomerization is one of the main therapeutic approaches in order to develop neurodegenerative-modifying agents. Because the folding and refolding of alpha synuclein is the key point of this cascade, we are interested in this review to summarize the role of some molecular chaperones proteins such as Hsp70, Hsp90 and small heat shock proteins (sHsp) and Hsp 104. Hsp70 and its co-chaperone, Hsp70 and small heat shock proteins can prevent neurodegeneration by preventing -syn misfolding, oligomerization and aggregation in vitro and in Parkinson disease animal models. Hsp104 is able to resolve disordered protein aggregates and cross beta amyloid conformers. Together, these chaperones have a complementary effect and can be a target for therapeutic intervention in PD. |
| File Format | HTM / HTML |
| ISSN | 01418130 |
| Volume Number | 60 |
| e-ISSN | 18790003 |
| Journal | International Journal of Biological Macromolecules |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2013-09-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Biochemistry Molecular Chaperones Metabolism Parkinson Disease Proteostasis Deficiencies Alpha-synuclein Animals Biological Markers Heat-shock Proteins Chemistry Humans Lewy Bodies Pathology Protein Folding Journal Article Review |
| Content Type | Text |
| Resource Type | Article |
| Subject | Structural Biology Molecular Biology Biochemistry |
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